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Abteilung für Neuropathologie

Forschung / Research

Research focus 

Our lab investigates the molecular genetic basis of human brain tumors. Gliomas are the most common human primary brain tumors and are central to our research efforts. These tumors harbor an intrinsic ability to malignant progression and they tend to diffusely infiltrate the surrounding brain tissue, thus limiting the efficiacy of local therapeutic approaches. Consequently, an improved understanding of the molecular genetic abberrations and signaling pathways underlying glioma cell invasion and glial tumor progession appears of considerable importance for the development of more efficient and targeted tumor therapies.

To achieve this goal, our laboratory emphasizes the combination of in vitro-techniques with histology-based approaches that allow for the direct study of molecular changes in human glioma tissue specimens. A main methodical focus is on the identification and functional characterization of genes that are epigentically regulated in gliomas, either by means of promoter methylation, aberrant histone modification patterns or a regulatory network of small, non-coding RNAs (so-called miRNAs). Our translational research approach enables us to convey basic research results into clinical neuropathological applications with the aim of identifying novel diagnostic and prognostic biomarkers. 

Our research is generously funded by the German Cancer Aid (Max Eder Junior Research Group Programme), the Wilhelm Sander Foundation (Therapy Unit Neurooncology), the Academy of Sciences Northrhine-Westfalia (Junges Kolleg/Mercator Foundation) and the Sibylle Assmus Research Award 2011 for Neurooncology. Additionally, our lab participates in the Bavarian Research Network on induced pluripotent stem cells (ForIPS) funded by the Bavarian State Ministry of Education, Science and the Arts.

> Publications on PubMed

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Beruf und Karriere
Universität Regensburg