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AG Prof. Böger

Current Projects

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Genome wide association studies (GWAS) of eGFR, albuminuria and kidney function change over time

As active members of the CKDGen Analyst Group, we are participating in GWAS meta-analyses of renal phenotypes in the CKDGen consortium since 2009 (see publications). Currently, more than 30 cohorts with a total of over 130000 individuals are participating in CKDGen’s endeavour to unravel the genetics of kidney traits.
Our group is contributing to this effort with the data sets of three cohorts:
KORA F3 and KORA F4, representative samples of the general population recruited from the region around Augsburg, Germany.
GENDIAN, a case control study of type-2-diabetes associated kidney disease.

Current CKDGen projects include GWAS of eGFR using 1000 Genomes imputed data sets and Exome Chip data sets. Further, completed meta-analyses of eGFR and albuminuria are currently in the stage of manuscript writing.

Epidemiology of diabetes mellitus type 2 associated end points in

We have recruited two cohorts for the study of micro- and macrovascular end points in patients with diabetes mellitus type 2:

  1. DIACORE (DIAbetes COhoRtE, http://www.diacore.de , PI: Carsten A. Böger) is a prospective cohort study of 3000 patients of self-reported Caucasian ethnicity with prevalent diabetes mellitus type 2 (DM2), recruited between 2/2010 and 3/2014. 2-year follow-up examinations are planned every 2 years for 10 years. The first follow-up examination has started in August 2013. Study visits are performed in University-based recruiting clinics in Germany using standard operating procedures. All prevalent DM2 patients in outpatient clinics surrounding the recruiting centers are invited to participate. At baseline and at each 2-year follow-up examination, patients are subjected to a core phenotyping protocol. This includes a standardized online questionnaire and physical examination to determine incident micro- and macrovascular DM2 complications, malignancy and hospitalization. Confirmatory outcome information is requested from patient records. Blood samples are obtained for a centrally analyzed standard laboratory panel and for biobanking of aliquots of serum, plasma, urine, mRNA and DNA for future scientific use. A subset of the cohort is subjected to extended phenotyping, including sleep apnea screening, skin autofluorescence measurement, non-mydriatic retinal photography and non-invasive determination of arterial stiffness.
    Reference:
    Dörhöfer L, Lammert A, Krane V, Gorski M, Banas B, Wanner C, Krämer BK, Heid IM, Böger CA; DIACORE Study Group. Study design of DIACORE (DIAbetes COhoRtE) - a cohort study of patients with diabetes mellitus type 2.
    BMC Med Genet. 2013 Feb 14;14:25. doi: 10.1186/1471-2350-14-25.
  2. GENDIAN (GENetics of DIAbetic Nephropathy, PI: Carsten A. Böger) is a case control study of diabetes associated nephropathy in Caucasian subjects. Cases are n=438 prevalent patients on maintenance hemodialysis due to diabetic nephropathy, recruited from 30 dialysis centers in Southern Germany between August 1999 and January 2000, and n=84 patients with biopsy proven diabetic nephropathy. A total of n=450 controls not on renal replacement therapy were recruited  in a large diabetes clinic in Southern Germany (Diabetes Zentrum Mergentheim). Follow-up examinations were performed in all cases and controls to assess incident cardiovascular events.
    References:
    Böger CA et al: effect of ACE and AT-2 inhibitors on mortality and progression to microalbuminuria in a nested case control study of diabetic nephropathy in diabetes mellitus type 2: results from the GENDIAN study. Int J Clin Pharmacol Ther 2006;44:364-74.
    Böger CA et al. Association of eGFR-related loci identified by GWAS with incident CKD and ESRD. Plos Genet 2011;7:e1002292.

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