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Klinik und Poliklinik für Innere Medizin III

Publikationen 2013  2012   2011   2010   2009   2008   2007   2006   2005   2004

Publikationen 2017  

Klobuch S, Weber D, Holler B, Herr W, Holler E, Wolff D. Potential Role of the PD-1/PD-L1 Axis in the Immune Regulation of Chronic GVHD. In: Oncol Res Treat. 2017;40(7-8):447-450.   

Hierl M, Pfirstinger J, Andreesen R, Holler E, Mayer S, Wolff D, Vogelhuber M. Complementary and Alternative Medicine: A Clinical Study in 1,016 Hematology/Oncology Patients. In: Oncology. 2017 Jun 23. doi: 10.1159/000464248. [Epub ahead of print]  

Pulewka K, Wolff D, Herzberg PY, Greinix H, Heussner P, Mumm FHA, von Harsdorf S, Rieger K, Hemmati P, Hochhaus A, Hilgendorf I. Physical and Psychosocial Aspects of Adolescent and Young Adults after Allogeneic Hematopoietic Stem Cell Transplantation - Results from a Prospective Multicenter Trial. In: J Cancer Res Clin Oncol. 2017 Aug;143(8):1613-1619.

Dullinger K, Pamler I, Brosig A, Mohrez M, Hähnel V, Offner R, Dormann F, Becke C, Holler E, Ahrens N. Granulocytapheresis with modified fluid gelatin versus high-molecular-weight hydroxyethyl starch: a matched-pair analysis. In: Transfusion. 2017 Feb;57(2):397-403.  

Bouazzaoui A, Huber E, Dan A, Al-Allaf FA, Pfirstinger J, Sprotte G, Köstler J, Hiergeist A, Gessner A, Herr W, Holler E. Reduction of aGVHD using chicken antibodies directed against intestinal pathogens in a murine model. In: Blood. 2017 Feb 23;129(8):1052-1055.  

Bohmann EM, Fehn U, Holler B, Weber D, Holler E, Herr W, Hoffmann P, Edinger M, Wolff D. Altered immune-reconstitution of B and T cells precedes the onset of clinical symptoms of chronic graft-versus-host disease and is influenced by the type of onset. In: Annals of Hematology 2017 Feb;96(2):299-310.

Leidgens V, Proske J, Rauer L, Moeckel S, Renner K, Bogdahn U, Riemenschneider MJ, Proescholdt M, Vollmann-Zwerenz A, Hau P, Seliger C. Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation. In: Oncotarget. 2017 Jan 31;8(5):8250-8263.  

Hierl M, Pfirstinger J, Andreesen R, Holler E, Mayer S, Wolff D, Vogelhuber M. Complementary and Alternative Medicine: A Clinical Study in 1,016 Hematology/Oncology Patients. In:2017 Jun 23. doi: 10.1159/000464248. [Epub ahead of print]  

Hohensee I, Chuang HN, Grottke A, Werner S, Schulte A, Horn S, Lamszus K, Bartkowiak K, Witzel I, Westphal M, Matschke J, Glatzel M, Jücker M, Pukrop T, Pantel K, Wikman H. PTEN mediates the cross talk between breast and glial cells in brain metastases leading to rapid disease progression. In: Oncotarget. 2017 Jan 24;8(4):6155-6168.   

Dräger J, Simon-Keller K, Pukrop T, Klemm F, Wilting J, Sticht C, Dittmann K, Schulz M, Leuschner I, Marx A, Hahn H. LEF1 reduces tumor progression and induces myodifferentiation in a subset of rhabdomyosarcoma. In: Oncotarget. 2017 Jan 10;8(2):3259-3273.  

Muqaku B, Eisinger M, Meier SM, Tahir A, Pukrop T, Haferkamp S, Slany A, Reichle A, Gerner C. Multi-omics Analysis of Serum Samples Demonstrates Reprogramming of Organ Functions Via Systemic Calcium Mobilization and Platelet Activation in Metastatic Melanoma. In: Mol Cell Proteomics. 2017 Jan;16(1):86-99.   

Juric MK, Shevtsov M, Mozes P, Ogonek J, Crossland RE, Dickinson AM, Greinix HT, Holler E, Weissinger EM, Multhoff G. B-Cell-Based and Soluble Biomarkers in Body Liquids for Predicting Acute/Chronic Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation. In: Front Immunol. 2017 Jan 16;7:660.  

Hilgendorf I, Greinix H, Halter J, Lawitschka A, Wolff D. Vaccination of allogeneic haematopoietic stem cell transplant recipients – what should be considered? In: Ann Hematol. 2017 Apr;96(4):701-702.     

Publikationen 2016    

Weißflog G, Hönig K, Gündel H, Lang D, Niederwieser D, Döhner H, Vogelhuber M, Mehnert A, Ernst J. Associations between dyadic coping and supportive care needs: findings from a study with hematologic cancer patients and their partners. In: Support Care Cancer. 2016 Dec 16. [Epub ahead of print]  

Roider T, Katzfuß M, Matos C, Singer K, Renner K, Oefner PJ, Dettmer-Wilde K, Herr W, Holler E, Kreutz M, Peter K. Antithymocyte Globulin Induces a Tolerogenic Phenotype in Human Dendritic Cells. In: Int J Mol Sci. 2016 Dec 11;17(12).

Hart C, Vogelhuber M, Hafner C, Landthaler M, Berneburg M, Haferkamp S, Herr W, Reichle A. Biomodulatory metronomic therapy in stage IV melanoma is well-tolerated and may induce prolonged progression-free survival, a phase I trial. In: J Eur Acad Dermatol Venereol. 2016 Nov;30(11):e119-e121.  

Weissinger EM, Human C, Metzger J, Hambach L, Wolf D, Greinix HT, Dickinson AM, Mullen W, Jonigk D, Kuzmina Z, Kreipe H, Schweier P, Böhm O, Türüchanow I, Ihlenburg-Schwarz D, Raad J, Durban A, Schiemann M, Könecke C, Diedrich H, Holler E, Beutel G, Krauter J, Ganser A, Stadler M. The proteome pattern cGvHD_MS14 allows early and accurate prediction of chronic GvHD after allogeneic stem cell transplantation. In: Leukemia. 2016 Nov 4. doi: 10.1038/leu.2016.259. [Epub ahead of print]  

Ullrich E, Salzmann-Manrique E, Bakhtiar S, Bremm M, Gerstner S, Herrmann E, Bader P, Hoffmann P, Holler E, Edinger M, Wolff D. Relation between acute GVHD and NK cell subset reconstitution following allogeneic stem cell transplantation. In: Frontiers in Immunology 2016 Dec 22;7:595.   

Schlenk RF, Lübbert M, Benner A, Lamparter A, Krauter J, Herr W, Martin H, Salih HR, Kündgen A, Horst HA, Brossart P, Götze K, Nachbaur D, Wattad M, Köhne CH, Fiedler W, Bentz M, Wulf G, Held G, Hertenstein B, Salwender H, Gaidzik VI, Schlegelberger B, Weber D, Döhner K, Ganser A, Döhner H; German-Austrian Acute Myeloid Leukemia Study Group. All-trans retinoic acid as adjunct to intensive treatment in younger adult patients with acute myeloid leukemia: results of the randomized AMLSG 07-04 study. In: Ann Hematol. 2016 Dec;95(12):1931-1942.

Ogonek J, Kralj Juric M, Ghimire S, Varanasi PR, Holler E, Greinix H, Weissinger E. Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation. In: Front Immunol. 2016 Nov 17;7:507.  

Juric MK, Ghimire S, Ogonek J, Weissinger EM, Holler E, van Rood JJ, Oudshoorn M, Dickinson A, Greinix HT. Milestones of Hematopoietic Stem Cell Transplantation - From First Human Studies to Current Developments. In: Front Immunol. 2016 Nov 9;7:470. eCollection 2016.  

Straka C, Liebisch P, Salwender H, Hennemann B, Metzner B, Knop S, Adler-Reichel S, Gerecke C, Wandt H, Bentz M, Bruemmendorf TH, Hentrich M, Pfreundschuh M, Wolf HH, Sezer O, Bargou R, Jung W, Trümper L, Hertenstein B, Heidemann E, Bernhard H, Lang N, Frickhofen N, Hebart H, Schmidmaier R, Sandermann A, Dechow T, Reichle A, Schnabel B, Schäfer-Eckart K, Langer C, Gramatzki M, Hinke A, Emmerich B, Einsele H. Autotransplant with and without induction chemotherapy in older multiple myeloma patients: long-term outcome of a randomized trial. In: Haematologica. 2016 Nov;101(11):1398-1406.  

Hart C, Klatt S, Barop J, Müller G, Schelker R, Holler E, Huber E, Herr W, Grassinger J. Splenic pooling and loss of VCAM-1 causes an engraftment defect in patients with myelofibrosis after allogeneic hematopoietic stem cell transplantation. In: Haematologica. 2016 Nov;101(11):1407-1416.  

Grube M, Wolff D, Ahrens N, Herzberg PY, Herr W, Holler E. ABO blood group antigen mismatch has an impact on outcome after allogeneic peripheral blood stem cell transplantation. In: Clin Transplant. 2016 Nov;30(11):1457-1465.  

Brand A, Singer K, Koehl GE, Kolitzus M, Schoenhammer G, Thiel A, Matos C, Bruss C, Klobuch S, Peter K, Kastenberger M, Bogdan C, Schleicher U, Mackensen A, Ullrich E, Fichtner-Feigl S, Kesselring R, Mack M, Ritter U, Schmid M, Blank C, Dettmer K, Oefner PJ, Hoffmann P, Walenta S, Geissler EK, Pouyssegur J, Villunger A, Steven A, Seliger B, Schreml S, Haferkamp S, Kohl E, Karrer S, Berneburg M, Herr W, Mueller-Klieser W, Renner K, Kreutz M. LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells. In: Cell Metab. 2016 Nov 8;24(5):657-671.  

Wanke D, Mauch-Mücke K, Holler E, Hehlgans T. Human beta-defensin-2 and -3 enhance pro-inflammatory cytokine expression induced by TLR ligands via ATP-release in a P2X7R dependent manner. In: Immunobiology. 2016 Nov;221(11):1259-65.

Schmid PM, Bouazzaoui A, Schmid K, Birner CM, Schach C, Maier LS, Holler E, Endemann DH. Vascular Alterations in a Murine Model of Acute Graft-Versus-Host Disease Are Associated With Decreased Serum Levels of Adiponectin and an Increased Activity and Vascular Expression of Indoleamine 2,3-Dioxygenase. In: Cell Transplant. 2016 Nov;25(11):2051-2062.  

Holler E, Weber D. Fit for cure? Microbiota and GVHD. In: Blood. 2016 Oct 20;128(16):2004-2005.  

Brosig A, Hähnel V, Orsó E, Wolff D, Holler E, Ahrens N. Technical comparison of four different extracorporeal photopheresis systems. In: Transfusion. 2016 Oct;56(10):2510-2519.  

Granata C, Oliveira RS, Little JP, Renner K, Bishop DJ. Mitochondrial adaptations to high-volume exercise training are rapidly reversed after a reduction in training volume in human skeletal muscle. In: FASEB J. 2016 Oct;30(10):3413-3423.

Weiß KT, Fante M, Köhl G, Schreml J, Haubner F, Kreutz M, Haverkampf S, Berneburg M, Schreml S. Proton-sensing G protein-coupled receptors (GPCRs) as regulators of cell proliferation and migration during tumor growth and wound healing. In: Exp Dermatol. 2016 Sep 13. doi: 10.1111/exd.13209. [Epub ahead of print].  

Holtan SG, Khera N, Levine JE, Chai X, Storer B, Liu HD, Inamoto Y, Chen GL, Mayer S, Arora M, Palmer J, Flowers ME, Cutler CS, Lukez A, Arai S, Lazaryan A, Newell LF, Krupski C, Jagasia MH, Pusic I, Wood W, Renteria AS, Yanik G, Hogan WJ, Hexner E, Ayuk F, Holler E, Watanaboonyongcharoen P, Efebera YA, Ferrara JL, Panoskaltsis-Mortari A, Weisdorf D, Lee SJ, Pidala J. Late acute graft versus host disease: a prospective analysis of clinical outcomes and circulating angiogenic factors. In: Blood. 2016 Sep 13. pii: blood-2015-09-669846. [Epub ahead of print].

Schiechl G, Hermann FJ, Rodriguez Gomez M, Kutzi S, Schmidbauer K, Talke Y, Neumayer S, Goebel N, Renner K, Brühl H, Karasuyama H, Obata-Ninomiya K, Utpatel K, Evert M, Hirt SW, Geissler EK, Fichtner-Feigl S, Mack M. Basophils Trigger Fibroblast Activation in Cardiac Allograft Fibrosis Development. In: Am J Transplant. 2016 Sep;16(9):2574-88.

Herr W, Eichinger Y, Beshay J, Bloetz A, Vatter S, Mirbeth C, Distler E, Hartwig UF, Thomas S. HLA-DPB1 mismatch alleles represent powerful leukemia rejection antigens in CD4 T-cell immunotherapy after allogeneic stem-cell transplantation. In: Leukemia. 2016 Sep 2. doi: 10.1038/leu.2016.210. [Epub ahead of print].

Cahill EF, Sax T, Hartmann I, Haffner S, Holler E, Holler B, Huss R, Günther C, Parolini O, Kolch W, Eissner G. Mesenchymal Stromal Cells Protect Endothelial Cells from Cytotoxic T Lymphocyte-Induced Lysis.  In: Scand J Immunol. 2016 Sep;84(3):158-64.  

Schiechl G, Hermann FJ, Rodriguez Gomez M, Kutzi S, Schmidbauer K, Talke Y, Neumayer S, Goebel N, Renner K, Brühl H, Karasuyama H, Obata-Ninomiya K, Utpatel K, Evert M, Hirt SW, Geissler EK, Fichtner-Feigl S, Mack M. Basophils Trigger Fibroblast Activation in Cardiac Allograft Fibrosis Development. In: Am J Transplant. 2016 Sep;16(9):2574-88.

Hoja S, Schulze M, Rehli M, Proescholdt M, Herold-Mende C, Hau P, Riemenschneider MJ. Molecular dissection of the valproic acid effects on glioma cells. In: Oncotarget. 2016 Aug 18. doi: 10.18632/oncotarget.11379. [Epub ahead of print].  

Cidlinsky N, Dogliotti G, Pukrop T, Jung R, Weber F, Krahn MP. Inactivation of the LKB1-AMPK signaling pathway does not contribute to salivary gland tumor development - a short report. In: Cell Oncol (Dordr). 2016 Aug;39(4):389-96.

Büchner T, Krug UO, Peter Gale R, Heinecke A, Sauerland MC, Haferlach C, Schnittger S, Haferlach T, Müller-Tidow C, Stelljes M, Mesters RM, Serve HL, Braess J, Spiekermann K, Staib P, Grüneisen A, Reichle A, Balleisen L, Eimermacher H, Giagounidis A, Rasche H, Lengfelder E, Görlich D, Faldum A, Köpcke W, Hehlmann R, Wörmann BJ, Berdel WE, Hiddemann W. Age, not therapy intensity, determines outcomes of adults with acute myeloid leukemia. In: Leukemia. 2016 Aug;30(8):1781-4.  

Illerhaus G, Kasenda B, Ihorst G, Egerer G, Lamprecht M, Keller U, Wolf HH, Hirt C, Stilgenbauer S, Binder M, Hau P, Edinger M, Frickhofen N, Bentz M, Möhle R, Röth A, Pfreundschuh M, von Baumgarten L, Deckert M, Hader C, Fricker H, Valk E, Schorb E, Fritsch K, Finke J. High-dose chemotherapy with autologous haemopoietic stem cell transplantation for newly diagnosed primary CNS lymphoma: a prospective, single-arm, phase 2 trial. In: Lancet Haematol. 2016 Aug;3(8):e388-97.  

Cidlinsky N, Dogliotti G, Pukrop T, Jung R, Weber F, Krahn MP. Inactivation of the LKB1-AMPK signaling pathway does not contribute to salivary gland tumor development - a short report. In: Cell Oncol (Dordr). 2016 Aug;39(4):389-96.  

Schwartz H, Blacher E, Amer M, Livneh N, Abramovitz L, Klein A, Ben-Shushan D, Soffer S, Blazquez R, Barrantes-Freer A, Müller M, Müller-Decker K, Stein R, Tsarfaty G, Satchi-Fainaro R, Umansky V, Pukrop T, Erez N. Incipient Melanoma Brain Metastases Instigate Astrogliosis and Neuroinflammation. In: Cancer Res. 2016 Aug 1;76(15):4359-71. 

Schoemans H, Goris K, Durm RV, Vanhoof J, Wolff D, Greinix H, Pavletic S, Lee SJ, Maertens J, Geest SD, Dobbels F, Duarte RF. Development, preliminary usability and accuracy testing of the EBMT 'eGVHD App' to support GvHD assessment according to NIH criteria-a proof of concept. In: Bone Marrow Transplant. 2016 Aug;51(8):1062-5.

Weber D, Oefner PJ, Dettmer K, Hiergeist A, Koestler J, Gessner A, Weber M, Stämmler F, Hahn J, Wolff D, Herr W, Holler E. Rifaximin preserves intestinal microbiota balance in patients undergoing allogeneic stem cell transplantation. In: Bone Marrow Transplant 2016 Aug;51(8):1087-92.

Haarer J, Riquelme P, Hoffmann P, Schnitzbauer A, Schlitt HJ, Sawitzki B, Geissler EK, Hutchinson JA. Early Enrichment and Restitution of the Peripheral Blood Treg Pool Is Associated With Rejection-Free Stable Immunosuppression After Liver Transplantation. In: Transplantation. 2016 Jul;100(7):e39-40.  

Seliger C, Meyer AL, Renner K, Leidgens V, Moeckel S, Jachnik B, Dettmer K, Tischler U, Gerthofer V, Rauer L, Uhl M, Proescholdt M, Bogdahn U, Riemenschneider MJ, Oefner PJ, Kreutz M, Vollmann-Zwerenz A, Hau P. Metformin inhibits proliferation and migration of glioblastoma cells independently of TGF-β2. In: Cell Cycle. 2016 Jul 2;15(13):1755-66.

Henrich FC, Singer K, Poller K, Bernhardt L, Strobl CD, Limm K, Ritter AP, Gottfried E, Völkl S, Jacobs B, Peter K, Mougiakakos D, Dettmer K, Oefner PJ, Bosserhoff AK, Kreutz MP, Aigner M, Mackensen A. Suppressive effects of tumor cell-derived 5'-deoxy-5'-methylthioadenosine on human T cells. In: Oncoimmunology. 2016 Jun 10;5(8):e1184802.  

Echtenacher B, Wege AK, Schardt K, Bitterer F, Gehmert S, Hoffmann P, Stroszczynski C, Jung EM. High-Resolution Ultrasound Including Contrast-Enhanced Ultrasound (CEUS) for the Detection of Gas Formation during Aspergillus Fumigatus Infection in Mice. In: Ultraschall Med. 2016 Jun;37(3):277-82.  

Stämmler F, Gläsner J, Hiergeist A, Holler E, Weber D, Oefner PJ, Gessner A, Spang R. Adjusting microbiome profiles for differences in microbial load by spike-in bacteria. In: Microbiome. 2016 Jun 21;4(1):28.  

Hume DA, Summers KM, Rehli M. Transcriptional Regulation and Macrophage Differentiation. In: Microbiol Spectr. 2016 Jun;4(3).  

Krug U, Berdel WE, Gale RP, Haferlach C, Schnittger S, Müller-Tidow C, Braess J, Spiekermann K, Staib P, Beelen D, Serve H, Schliemann C, Stelljes M, Balleisen L, Maschmeyer G, Grüneisen A, Eimermacher H, Giagounidis A, Rasche H, Hehlmann R, Lengfelder E, Thiel E, Reichle A, Aul C, Ludwig WD, Kern W, Haferlach T, Köpcke W, Görlich D, Sauerland MC, Heinecke A, Wörmann BJ, Hiddemann W, Büchner T. Increasing intensity of therapies assigned at diagnosis does not improve survival of adults with acute myeloid leukemia. In: Leukemia. 2016 Jun;30(6):1230-6.  

Ernst J, Hinz A, Niederwieser D, Döhner H, Hönig K, Vogelhuber M, Mehnert A, Weissflog G. Dyadic coping of patients with hematologic malignancies and their partners and its relation to quality of life - a longitudinal study. In: Leuk Lymphoma. 2016 Jun 22:1-11. [Epub ahead of print].  

Monin MB, Krause P, Stelling R, Bocuk D, Niebert S, Klemm F, Pukrop T, Koenig S. The anthelmintic niclosamide inhibits colorectal cancer cell lines via modulation of the canonical and noncanonical Wnt signaling pathway. In: J Surg Res. 2016 Jun 1;203(1):193-205.  

Hart C, Schmid S. [Coagulation disorders in the intensive care unit - what is new?]. In: Dtsch Med Wochenschr. 2016 Jun;141(11):777-80.

Ahmed SS, Wang XN, Norden J, Pearce K, El-Gezawy E, Atarod S, Hromadnikova I, Collin M, Holler E, Dickinson AM. Identification and validation of biomarkers associated with acute and chronic graft versus host disease. In: Bone Marrow Transplant. 2016 Jun;51(6):890.

Avellino R, Havermans M, Erpelinck C, Sanders MA, Hoogenboezem R, van de Werken HJ, Rombouts E, van Lom K, van Strien PM, Gebhard C, Rehli M, Pimanda J, Beck D, Erkeland S, Kuiken T, de Looper H, Gröschel S, Touw I, Bindels E, Delwel R. An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation. In: Blood. 2016 Jun 16;127(24):2991-3003.

Grube M, Holler E, Weber D, Holler B, Herr W, Wolff D. Risk Factors and Outcome of Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation-Results from a Single-Center Observational Study. In: Biol Blood Marrow Transplant 2016 Jun 22 [Epub ahead of print].  

Kariminia A, Holtan SG, Ivison S, Rozmus J, Hebert MJ, Martin PJ, Lee SJ, Wolff D, Subrt P, Abdossamadi S, Sung S, Storek J, Levings M, Aljurf MD, Arora M, Cutler C, Gallagher G, Kuruvilla J, Lipton J, Nevill TJ, Newell LF, Panzarella T, Pidala J, Popradi G, Szwajcer D, Tay J, Toze CL, Walker I, Couban S, Storer BE, Schultz KR. Heterogeneity of chronic graft-versus-host disease biomarkers: the only consistent association is with CXCL10 and CXCR3+ NK cells. In: Blood 2016 Jun 16;127(24):3082-91.

Assmann N, Dettmer K, Simbuerger JM, Broeker C, Nuernberger N, Renner K, Courtneidge H, Klootwijk ED, Duerkop A, Hall A, Kleta R, Oefner PJ, Reichold M, Reinders J. Renal Fanconi Syndrome Is Caused by a Mistargeting-Based Mitochondriopathy. In: Cell Rep. 2016 May 17;15(7):1423-9.

Heinzelmann F, Bethge W, Beelen DW, Engelhard M, Kröger N, Dreger P, Niederwieser D, Finke J, Bunjes D, Tischer J, Kobbe G, Holler E, Bornhäuser M, Stelljes M, Baurmann H, Müller A, Haubitz I, Schrezenmeier H, Müller C, Ottinger H. Allogeneic hematopoietic cell transplantation as curative therapy for non-transformed follicular lymphomas. In: Bone Marrow Transplant. 2016 May;51(5):654-62.

Bleckmann A, Conradi LC, Menck K, Schmick NA, Schubert A, Rietkötter E, Arackal J, Middel P, Schambony A, Liersch T, Homayounfar K, Beißbarth T, Klemm F, Binder C, Pukrop T. β-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases. In: Clin Exp Metastasis. 2016 Apr;33(4):309-23.  

Domschke C, Schneeweiss A, Stefanovic S, Wallwiener M, Heil J, Rom J, Sohn C, Beckhove P, Schuetz F. Cellular Immune Responses and Immune Escape Mechanisms in Breast Cancer: Determinants of Immunotherapy. In: Breast Care (Basel). 2016 Apr;11(2):102-7.  

Gigante M, Pontrelli P, Herr W, Gigante M, D'Avenia M, Zaza G, Cavalcanti E, Accetturo M, Lucarelli G, Carrieri G, Battaglia M, Storkus WJ, Gesualdo L, Ranieri E. miR-29b and miR-198 overexpression in CD8+ T cells of renal cell carcinoma patients down-modulates JAK3 and MCL-1 leading to immune dysfunction. In: J Transl Med. 2016 Apr 11;14:84.  

Edinger M. Driving allotolerance: CAR-expressing Tregs for tolerance induction in organ and stem cell transplantation. In: J Clin Invest. 2016 Apr 1;126(4):1248-50.

Bleckmann A, Conradi LC, Menck K, Schmick NA, Schubert A, Rietkötter E, Arackal J, Middel P, Schambony A, Liersch T, Homayounfar K, Beißbarth T, Klemm F, Binder C, Pukrop T. β-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases. In: Clin Exp Metastasis. 2016 Apr;33(4):309-23.

Wolff D, Hildebrandt G.  Bronchiolitis Obliterans: Pleading for a Pragmatic Approach. In: Biology of Blood & Marrow Transplantation 2016 Apr;22(4):591-3.

Knies D, Klobuch S, Xue SA, Birtel M, Echchannaoui H, Yildiz O, Omokoko T, Guillaume P, Romero P, Stauss H, Sahin U, Herr W, Theobald M, Thomas S, Voss RH. An optimized single chain TCR scaffold relying on the assembly with the native CD3-complex prevents residual mispairing with endogenous TCRs in human T-cells. In: Oncotarget. 2016 Apr 19;7(16):21199-221.

Peled JU, Jenq RR, Holler E, van den Brink MR. Role of gut flora after bone marrow transplantation. In: Nat Microbiol. 2016 Mar 29;1:16036.  

Gratwohl A, Pfirrmann M, Zander A, Kröger N, Beelen D, Novotny J, Nerl C, Scheid C, Spiekermann K, Mayer J, Sayer HG, Falge C, Bunjes D, Döhner H, Ganser A, Schmidt-Wolf I, Schwerdtfeger R, Baurmann H, Kuse R, Schmitz N, Wehmeier A, Fischer JT, Ho AD, Wilhelm M, Goebeler ME, Lindemann HW, Bormann M, Hertenstein B, Schlimok G, Baerlocher GM, Aul C, Pfreundschuh M, Fabian M, Staib P, Edinger M, Schatz M, Fauser A, Arnold R, Kindler T, Wulf G, Rosselet A, Hellmann A, Schäfer E, Prümmer O, Schenk M, Hasford J, Heimpel H, Hossfeld DK, Kolb HJ, Büsche G, Haferlach C, Schnittger S, Müller MC, Reiter A, Berger U, Saußele S, Hochhaus A, Hehlmann R; SAKK; German CML Study Group. Long-term outcome of patients with newly diagnosed chronic myeloid leukemia: a randomized comparison of stem cell transplantation with drug treatment. In: Leukemia. 2016 Mar;30(3):562-9.  

Ho AD, Schetelig J, Bochtler T, Schaich M, Schäfer-Eckart K, Hänel M, Rösler W, Einsele H, Kaufmann M, Serve H, Berdel WE, Stelljes M, Mayer J, Reichle A, Baldus CD, Schmitz N, Kramer M, Röllig C, Bornhäuser M, Thiede C, Ehninger G, Study Alliance Leukemia. Allogeneic Stem Cell Transplantation Improves Survival in Patients with Acute Myeloid Leukemia Characterized by a High Allelic Ratio of Mutant FLT3-ITD. In: Biol Blood Marrow Transplant. 2016 Mar;22(3):462-9.

Müller-Tidow C, Tschanter P, Röllig C, Thiede C, Koschmieder A, Stelljes M, Koschmieder S, Dugas M, Gerss J, Butterfaß-Bahloul T, Wagner R, Eveslage M, Thiem U, Krause SW, Kaiser U, Kunzmann V, Steffen B, Noppeney R, Herr W, Baldus CD, Schmitz N, Götze K, Reichle A, Kaufmann M, Neubauer A, Schäfer-Eckart K, Hänel M, Peceny R, Frickhofen N, Kiehl M, Giagounidis A, Görner M, Repp R, Link H, Kiani A, Naumann R, Brümmendorf TH, Serve H, Ehninger G, Berdel WE, Krug U; Study Alliance Leukemia Group. Azacitidine in combination with intensive induction chemotherapy in older patients with acute myeloid leukemia: The AML-AZA trial of the Study Alliance. Leukemia. In: Leukemia 2016 Mar;30(3):555-61.

Distler E, Albrecht J, Brunk A, Khan S, Schnürer E, Frey M, Mottok A, Jordán-Garrote AL, Brede C, Beilhack A, Mades A, Tomsitz D, Theobald M, Herr W, Hartwig UF. Patient-individualized CD8(+) cytolytic T-cell therapy effectively combats minimal residual leukemia in immunodeficient mice. In: Int J Cancer. 2016 Mar 1;138(5):1256-68.

Granata C, Oliveira RS, Little JP, Renner K, Bishop DJ. Training intensity modulates changes in PGC-1α and p53 protein content and mitochondrial respiration, but not markers of mitochondrial content in human skeletal muscle. In: FASEB J. 2016 Feb;30(2):959-70.

Vrhovac R, Labopin M, Ciceri F, Finke J, Holler E, Tischer J, Lioure B, Gribben J, Kanz L, Blaise D, Dreger P, Held G, Arnold R, Nagler A, Mohty M. Second reduced intensity conditioning allogeneic transplant as a rescue strategy for acute leukaemia patients who relapse after an initial RIC allogeneic transplantation: analysis of risk factors and treatment outcomes. In: Bone Marrow Transplant. 2016 Feb;51(2):186-93.

Blecha C, Wolff D, Holler B, Holler E, Weber D, Vogt R, Helbig H, Dietrich-Ntoukas T. Verification of the new grading scale for ocular chronic graft-versus-host disease developed by the German-Austrian-Swiss consensus conference on chronic GVHD. In: Ann Hematol. 2016 Feb;95(3):493-9.

Ditz D, Rabanus R, Schulz C, Wolff D, Holler B, Holler E, Hildebrandt GC. The lung function score and its components as predictors of overall survival and chronic graft-vs-host disease after allogeneic stem cell transplantaion. In: Croat Med J . 2016 Feb 29;57(1):16-28.

Pulanić D, Desnica L, Vrhovac R, Nemet D, Wolff D, Greinix H, Pavletic SZ. Chronic graft-vs-host disease in 2016: a major challenge and an opportunity. In: Croat Med J. 2016 Feb;57(1):1-3.

Harris AC, Young R, Devine S, Hogan WJ, Ayuk F, Bunworasate U, Chanswangphuwana C, Efebera YA, Holler E, Litzow M, Ordemann R, Qayed M, Renteria AS, Reshef R, Wölfl M, Chen YB, Goldstein S, Jagasia M, Locatelli F, Mielke S, Porter D, Schechter T, Shekhovtsova Z, Ferrara JL, Levine JE. International, Multicenter Standardization of Acute Graft-versus-Host Disease Clinical Data Collection: A Report from the Mount Sinai Acute GVHD International Consortium. In: Biol Blood Marrow Transplant. 2016 Jan;22(1):4-10.

Ugocsai P, Wolff D, Menhart K, Hellwig D, Holler E, Herr W, Reichle A. Biomodulatory metronomic therapy induces PET-negative remission in chemo- and brentuximab-refractory Hodgkin lymphoma. In: Br J Haematol. 2016 Jan;172(2):290-3.

Schelker RC, Huber E, Herr W, Vogelhuber M. Marked regression of myelofibrosis during reduced-dose dasatinib treatment in chronic myelogenous leukemia in accelerated phase. In: Leuk Lymphoma. 2016;57(1):219-22.

Publikationen 2015

Siam L, Bleckmann A, Chaung HN, Mohr A, Klemm F, Barrantes-Freer A, Blazquez R, Wolff HA, Lüke F, Rohde V, Stadelmann Chr, Pukrop T. The metastatic infiltration at the metastasis/brain parenchyma-interface is very heterogeneous and has a significant impact on survival in a prospective study. In: Oncotarget advance publication (2015).

Menck K, Scharf C, Bleckmann A, Dyck L, Rost U, Wenzel D, Dhople VM, Siam L, Pukrop T, Binder C, Klemm F. Tumor-derived microvesicles mediate human breast cancer invasion through differentially glycosylated EMMPRIN. In: J Mol Cell Biol. 2015 7(2):143-53 (2015).

Rietkötter E, Bleckmann A, Bayerlová M, Menck K, Chuang H-N, Wenske B, Schwartz H, Erez N, Binder C, Hanisch UK, Pukrop T. Anti-CSF-1 treatment is effective to prevent carcinoma invasion induced by monocyte-derived cells but scarcely by microglia. In: Oncotarget (17):15482-93 (2015).

Stift, J., Baba, H.A., Huber, E., Federmann, B., Fischer, H.-P. Schmitt-Graeff, A., Baurmann, H., Bethge, W., Schirmacher, P., Wrba, F., Greinix, H., Fend, F., Schwerdtfeger, R., Shulman, H.M., Wolff, D. Longerich, T. Consensus on the histopathological evaluation of liver biopsies from patients following allogeneic hematopoietic cell transplantation. In: Virchows Archive 2014; 464, 175 - 190

Ch. Blecha, D. Wolff, B. Holler, E. Holler, D. Weber, R. Vogt, H. Helbig, T. Dietrich-Ntoukas. Verification of the new grading scale for ocular chronic graft-versus-host disease developed by the German-Austrian-Swiss consensus conference on chronic GVHD. In: Ann Hematol, 2015 Dec 14. [Epub ahead of print]

C. Blecha, D. Wolff, B. Holler, E. Holler, D. Weber, R. Vogt, H. Helbig, T. Dietrich-Ntoukas.
Verification of the new grading scale for ocular chronic graft-versus-host disease developed by the German-Austrian-Swiss Consensus Conference on chronic GVHD. In: Ann Hematol. 2015 Dec 14. [Epub ahead of print]

H. Schoemans, K. Goris, R. Van Durm, J. Vanhoof, D. Wolff, H. Greinix, S. Pavletic, S. Lee, J. Maertens, S. De Geest, F. Dobbels, R. F. Duarte. Development and preliminary usability and accuracy testing of the "EBMT GVHD App” to support graft versus host disease diagnosis and scoring according to NIH criteria. In: Bone Marrow Transplantation 2015 in press

C. Blecha, K. Angstwurm, D. Wolff, E. Holler, H. Helbig, J. Grassinger, J. Rennert, I. Kleiter, E. Huber, C. Schmid, T. Dietrich-Ntoukas. Retinal Involvement in a patient with cerebral manifestations of chronic graft-versus-host disease. In: Oncology Research and Treatment 2015; 38,532- 534

D. Weber, K. Dettmer, P. Oefner, A. Hiergeist, J. Koestler, A. Gessner, M. Weber, J. Hahn, D. Wolff, M. Kreutz, W. Herr, E. Holler. Low indoxylsufalte levels indicating loss of microbiome diversity predict poor outcome after allogeneic SCT and associate with NOD2/CARD15 polymorphisms. In: Blood 2015 in press

Balavarca Y., Pearce, K., Norden, J., Collin, M., Jackson, G., Holler, E., Dressel, R., Kolb, H.-J., Greinix, H., Socie, G., Toubert, A., Rocha, V., Gluckman, E., Hromadnikova, I., Sedlacek, P., Wolff, D., Holtick, U., Dickinson, A., Bickeböller, H. Predicting survival using clinical risk scores and non-HLA immunogenetics. In: Bone Marrow Transplantation in press 2015

P. J. Martin, S. J. Lee, D. Przepiorka, M. M. Horowitz, J. Koreth, G. B. Vogelsang, I. Walker, P. A. Carpenter, L. M. Griffith, G. Akpek, M. Mohty, D. Wolff, S. Z. Pavletic, C. S. Cutler. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: VI. The 2014 Clinical Trial Design Working Group Report. In: Biology of Blood & Marrow Transplantation in press 2015

S. Lee, D. Wolff, C. Kitko, J. Koreth, Y. Inamoto, M. Jagasia, J. Pidala, A. Olivieri, P. Martin, D. Przepiorka, I. Pusic, F. Dignan, S. Mitchell, A. Lawitschka, D. Jacobsohn, A. Hal, M. Flowers, K. Schultz, G. Vogelsang, S.Z. Pavletic. Measuring Therapeutic Response in Chronic Graft-versus-Host Disease. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2014 Response Criteria Working Group Report. In: Biology of Blood & Marrow Transplantation in press 2015 [Epub ahead of print]

M. Jagasia, H. Greinix, M. Arora, K. Williams, D. Wolff, E. Cowen, J. Palmer, D. Weisdorf, N. Treister, G.-S. Cheng, H. Kerr, P. Stratton, R. Duarte, G. McDonald, Y. Inamoto, A. Vigorito, S. Arai, M. Datiles, D. Jacobsohn, T. Heller, C. Kitko, S. Mitchell, P.J. Martin, H. Shulman, R. Wu, C. Cutler, G. Vogelsang, S.J. Lee, S.Z. Pavletic, M.E.D. Flowers. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group Report. In: Biology of Blood & Marrow Transplantation 2015 Mar;21(3):389-401

C. Hart, B. Heindl, M. Spannagl, S. Lison. A standardized treatment regimen for patients with severe haemophilia A undergoing orthopaedic or trauma surgery: a single centre experience. In: Blood Coagul Fibrinolysis  2015 Jun;26(4):396-402

Publikationen 2014

H. Greinix, Z. Kuzmina, R.Weigl, U. Körmoczi, A. Rottal, D. Wolff, M. Kralj, P. Kalhs, M. Mitterbaurer, W. Rabitsch, M. Edinger, E. Holler W. Pickl. CD19+CD21low B-cells and CD4+CD45RA+CD31+ T-cells correlate with first diagnosis of chronic graft-versus-host disease. In: Biology of Blood & Marrow Transplantation in press 2014

I. Hilgendorf, H. Greinix, J.P. Halter, A. Lawitschka, H. Bertz, D. Wolff. Langzeitnachsorge nach allogener Stammzelltransplantation. In: Deutsches Ärzteblatt, 2015; 4, 51-58.

A. Lawitschka, E. Gueclue, J. Varni, M. Putz, D. Wolff, S.Z. Pavletic, H. Greinix, Ch. Peters, R. Felder-Puig. Health-related quality of life in pediatric patients after allogeneic SCT: development of the PedsQL 1.0 Stem Cell Transplant Module and results of a pilot study. In: Bone Marrow Transplant 2014 Aug;49(8):1093-7. Epub 2014 May 12.

Tirri B. Frey, P. Häusermann, H. Bertz, H. Greinix, A. Lawitschka, C-P. Schwarze, D. Wolff, JP. Halter, D. Dörfler, R. Moffat. Clinical guidelines for gynecologic care after hematopoietic stem cell transplantation Report from the International Consensus Project on Clinical Practice in Chronic Graft-versus-Host Disease. In: Bone Marrow Transplant 2014 Oct 27. doi: 10.1038/bmt.2014.242. [Epub ahead of print]

U. Hillen, P. Häusermann, D. Massi, A. Janin, D. Wolff, A. Lawitschka, H. Greinix, R. Meyer, and M. Ziemer. Consensus on performing skin biopsies, laboratory workup, evaluation of tissue samples, and reporting of the results in patients with suspected cutaneous graft-versus-host disease. In: J. of European Academy of Dermatology and Venereology in press 2014

J. Pfirstinger, D. Kattner, M. Edinger, R. Andreesen, M. Vogelhuber. The Impact of a Tumor Diagnosis on Patients' Attitudes toward Advance Directives. In: Oncology. 2014 Aug 15;87(4):246-256. [Epub ahead of print] 

St. Mielke, M. Lutz, J. Schmidhuber, M. Kapp, D. Ditz, J. Ammer, H. Einsele, G.U. Grigoleit, E. Holler, D. Wolff. Salvage therapy with everolimus reduces the severity of treatment-refractory chronic graft-versus-host disease without impairing disease control: A dual center retrospective analysis. In: Bone Marrow Transplant in press 2014  

The FANTOM Consortium. (Joint first authors: ARR. Forrest, H. Kawaji, M. Rehli, JK. Baillie). A promoter-level mammalian expression atlas. In: Nature. 2014 Mar 27;507(7493):462-70.

R. Andersson, C. Gebhard, I. Miguel-Escalada, I. Hoof, J. Bornholdt, M. Boyd, Y. Chen, X. Zhao, C. Schmidl, T. Suzuki, E. Ntini, E. Arner, E. Valen, K. Li, L. Schwarzfischer, D. Glatz, J. Raithel, B. Lilje, N. Rapin, FO. Bagger, M. Jørgensen, PR. Andersen, N. Bertin, O. Rackham, AM. Burroughs, JK. Baillie, Y. Ishizu, Y. Shimizu, E. Furuhata, S. Maeda, Y. Negishi, CJ. Mungall, TF. Meehan, T. Lassmann, M. Itoh, H. Kawaji, N. Kondo, J. Kawai, A. Lennartsson, CO. Daub, P. Heutink, DA. Hume, TH. Jensen, H. Suzuki, Y. Hayashizaki, F. Müller; FANTOM Consortium, AR. Forrest, P. Carninci, M. Rehli, A. Sandelin. An atlas of active enhancers across human cell types and tissues. In: Nature. 2014 Mar 27;507(7493):455-61.

C. Schmidl, L. Hansmann, T. Lassmann, PJ. Balwierz, H. Kawaji, M. Itoh, J. Kawai, S. Nagao-Sato, H. Suzuki, R. Andreesen, Y. Hayashizaki, AR. Forrest, P. Carninci, P. Hoffmann, M. Edinger, M. Rehli; FANTOM consortium. The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations. In: Blood. 2014 Apr 24;123(17):e68-78.

C. Schmidl, K. Renner, K. Peter, R. Eder, T. Lassmann, PJ Balwierz, M. Itoh, S. Nagao-Sato, H. Kawaji, P. Carninci, H. Suzuki, Y. Hayashizaki, R. Andreesen, DA. Hume, P. Hoffmann, AR. Forrest, MP. Kreutz, M. Edinger, M. Rehli; FANTOM consortium. Transcription and enhancer profiling in human monocyte subsets. In: Blood. 2014 Apr 24;123(17):e90-9. 

J. Grassinger, A. Khomenko, C. Hart, D. Baldaranov, SW. Johannesen, G. Mueller, R. Schelker, W. Schulte-Mattler, R. Andreesen, U. Bogdahn. Safety and feasibility of long term administration of recombinant human granulocyte-colony stimulating factor in patients with amyotrophic lateral sclerosis. In: Cytokine. 2014 May;67(1):21-8.  

A. Lawitschka, ED. Güclü, JW. Varni, M. Putz, D. Wolff, S. Pavletic, H. Greinix, C. Peters, R. Felder-Puig. Health-related quality of life in pediatric patients after allogeneic SCT: development of the PedsQL Stem Cell Transplant module and results of a pilot study. In: Bone Marrow Transplant. 2014 May 12. [Epub ahead of print]

J. Stift, HA. Baba, E. Huber, B. Federmann, HP. Fischer, A. Schmitt-Graeff, H. Baurmann, W. Bethge, P. Schirmacher, F. Wrba, H. Greinix, F. Fend, R. Schwerdtfeger, HM. Shulman, D. Wolff, T. Longerich; Liver Pathology Group of the German-Austrian-Swiss Working Group on GvHD. Consensus on the histopathological evaluation of liver biopsies from patients following allogeneic hematopoietic cell transplantation. In: Virchows Arch. 2014 Feb;464(2):175-90.

C. Blecha, D. Wolff, O. Kölbl, E. Huber, H. Helbig, B. Holler, E. Holler, T. Dietrich-Ntoukas. Isolated orbital relapse of multiple myeloma in a patient with severe chronic GVHD after allogeneic hematopoietic SCT. In: Bone Marrow Transplant. 2014 Apr 28.  [Epub ahead of print] 

E. Holler, P. Butzhammer, K. Schmid, C. Hundsrucker, J. Koestler, K. Peter K, W. Zhu, D. Sporrer, T. Hehlgans, M. Kreutz, B. Holler, D. Wolff, M. Edinger, R. Andreesen, JE. Levine, JL Ferrara, A. Gessner, R. Spang, PJ. Oefner. Metagenomic analysis of the stool microbiome in patients receiving allogeneic stem cell transplantation: loss of diversity is associated with use of systemic antibiotics and more pronounced in gastrointestinal graft-versus-host disease. In: Biol Blood Marrow Transplant. 2014 May;20(5):640-5.  

C. Hofmann, N. Dunger, K. Doser, E. Lippert, S. Siller, M. Edinger, W. Falk, F. Obermeier F. Physiologic TLR9-CpG-DNA interaction is essential for the homeostasis of the intestinal immune system. In: Inflamm Bowel Dis. 2014 Jan;20(1):136-43.  


KF. Pearce, M. Hildebrandt, H. Greinix, S. Scheding, U. Koehl, N. Worel, J. Apperley, M. Edinger, A. Hauser, E. Mischak-Weissinger, AM Dickinson, MW Lowdell. Regulation of advanced therapy medicinal products in Europe and the role of academia. In: Cytotherapy. 2014 Mar;16(3):289-97.  

PM. Schmid, A. Bouazzaoui, K. Doser, K. Schmid, P. Hoffmann, JA. Schroeder, GA. Riegger, E. Holler, DH. Endemann. Endothelial Dysfunction and Altered Mechanical and Structural Properties of Resistance Arteries in a Murine Model of GvHD. In: Blood Marrow Transplant. 2014 May 7. [Epub ahead of print] 

S. Thomas, S. Klobuch, M. Sommer, R. van Ewijk, M. Theobald, RG. Meyer, W. Herr. Human CD8+ memory and EBV-specific T cells show low alloreactivity in vitro and in CD34+ stem cell-engrafted NOD/SCID/IL-2Rγc null mice. In: Exp Hematol. 2014 Jan;42(1):28-38. 

C. Hart, M. Spannagl. Coagulation disorders in the intensive care station. In: Internist (Berl). 2014 May;55(5):521-8.

A. Bouazzaoui, S.Dickhöfer, M. Kreutz, E. Huber, E. Holler, D. Wolff. Cytostatic conditioning in experimental allogeneic bone marrow Transplantation. Busulfan causes less early gastrointestinal toxicity but Treosulfan results in improved immune reconstitution. In: Immunopharmacol Immunotoxicol. 2014 Apr;36(2):158-64.

Publikationen 2013 


I. Hilgendorfa, D. Wolff. Treatment options for graft-versus-host disease. In: Expert Opinion on Orphan Drugs Volume 1,  Issue 9, 2013

C. Hart, M. Spannagl, S. Kluge, A. Markewitz, E. Muhl, C. Putensen, M. Quintel, G.W. Sybrecht. Direkte Antikoagulantien. Gerinnungsmonitoring und Blutungsmanagement. In: DIVI Jahrbuch 2013/2014. MWM, 2014, S. 249-256.

C. Hart, M. Spannagl. Monitoring der direkten oralen Antikoagulanzien. In: Kardio up 2013; 09(03): 197-211.

J. Stift, H. A. Baba, E. Huber, B. Federmann, H-P. Fischer, A. Schmitt-Graeff, H. Baurmann, W. Bethge, P. Schirmacher, F. Wrba, H. Greinix, F. Fend, R. Schwerdtfeger, H. M. Shulman, D. Wolff, Th. Longerich. Consensus on the histopathological evaluation of liver biopsies from patients following allogeneic hematopoietic cell transplantation. In: Virchows Archive 2014 Feb;464(2):175-90.

K. Dettmer, FC. Vogl, AP. Ritter, W. Zhu, N. Nürnberger, M. Kreutz, PJ. Oefner, W. Gronwald, E. Gottfried. Distinct metabolic differences between various human cancer and primary cells. In: Electrophoresis. 2013 Oct;34(19):2836-2847.

KF. Pearce, M. Hildebrandt, H. Greinix, S. Scheding, U. Koehl, N. Worel , J. Apperley, M. Edinger, A. Hauser, E. Mischak-Weissinger, AM. Dickinson, MW Lowdell. Regulation of advanced therapy medicinal products in Europe and the role of academia. In: Cytotherapy . 2013 Oct 8. S1465-3249(13)00671-3. [Epub ahead of print]

SL. Ellis , SY. Heazlewood , B. Williams, AJ. Reitsma, J. Grassinger, J. Borg, CK. Heazlewood, AP. Chidgey, SK. Nilsson. The role of Tenascin C in the lymphoid progenitor cell niche. In: Exp Hematol. 2013 Sep 28. pii: S0301-472X(13)00744-3. Epub ahead of print. 

SD Diermeier, A. Németh, M. Rehli, I. Grummt, G. Längst. Chromatin-Specific Regulation of Mammalian rDNA Transcription by Clustered TTF-I Binding Sites. PloS Genet. 2013 Sep;9(9);e1003784.

C. Durutel, F. Bergmann, I. Rooman, M. Zucknick, D. Weichenhan, L. Geiselhart, T. Kaffenberger, PS. Rachakonda, A. Bauer, N. Giese, C. Hong, H. Xie, JF. Costello, J. hoheisel, R. Kumar, M. Rehli, P. Schirmacher, J. Werner, C. Plass, O. Popanda, P. Schmezer. Early epigenetic downregulation of WNK2 kinade during panreatic ductal adenocarcinoma development. In: Oncogene. 2013 Aug 5. Epub ahead of print.

M. Ziemer, P. Haeusermann, A. Janin, D. Massi, M. Ziepert, D. Wolff, H. Greinix, U. Hillen. Histopathological diagnosis of graft-versus-host disease of the skin - an inter-observer comparison. In: J Eur Acad Dermatol Venereol 2013 Aug 1. Epub ahead of print.

R.F. Duarte, H. Greinix, B. Rabin, S.A. Mitchell, G. Basak, D. Wolff, J.A. Madrigal, S.Z. Pavletic, S.J. Lee. Uptake and use of recommendations for the diagnosis, severity scoring and management of chronic graft-versus-host disease: an international survey of the EBMT-NCI Chronic GVHD Task Force . In: Bone Marrow Transplant 2013 Aug 19. Epub ahead of print. 

Th. Pham, J. Minderjahn, C. Schmidl, H. Hoffmeister, C. Schmidhofer, W. Chen, G. Längst, C. Benner, M. Rehli. Mechanisms of in vivo binding site selection of the hematopoietic master transcription factor PU.1. In: Nucleic Acids Res. 2013; 41(13):6391-402. Epub 2013 May 8.

I. Kleiter, P. Poeschl, P.D. Kraus, E. Huber, J. Schröder, W. Schulte-Mattler, E. Holler, D. Wolff. Entrapment syndrome of multiple nerves in graft-versus-host disease. In: Muscle & Nerve 2013 Jul 28. Epub ahead of print.

E. Gottfried, SA. Lang, K. Renner, A. Bosserhoff, W. Gronwald, M. Rehli, S. Einhell, I. Gedig, K. Singer, A. Seilbeck, A. Mackensen, O. Grauer, P. Hau, K. Dettmer, R. Andreesen, PJ. Oefner, M. Kreutz. New Aspects of an Old Drug - Diclofenac Targets MYC and Glucose Metabolism in Tumor Cells. In: PLoS One. 2013 Jul 9;8(7).

E.M. Weissinger, J. Metzger, C. Dobbelstein, D. Wolff, M. Schleuning, Z. Kuzmina, H. Greinix, A.M. Dickinson, W. Mullen, H. Kreipe, I. Hamwi, M. Morgan, A. Krons, I. Tchebotarenko, D. Ihlenburg-Schwarz, E. Dammann, M. Collin, S. Ehrlich, H. Diedrich, M. Stadler, M. Eder, E. Holler, H. Mischak, J. Krauter, A. Ganser. Proteomic peptide profiling for preemptive diagnosis of acute graft-versus-host-disease after allogeneic stem cell transplantation.  In: Leukemia 2013 Jul 11. Epub ahead of print.

M. Klug, S. Schmidhofer, C. Gebhard, R. Andreesen, M. Rehli. 5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in Primary human monocytes. In: Genome Biol. 2013 May 26;14(5):R46. Epub ahead of print.

Wood WA, Chai X, Weisdorf D, Martin PJ, Cutler C, Inamoto Y, Wolff D, Pavletic SZ, Pidala J, Palmer JM, Arora M, Arai S, Jagasia M, Storer B, Lee SJ,, Mitchell S. Comorbidity burden in patients with chronic GVHD. In: Bone Marrow Transplant 2013 May 13. Epub ahead of print.

D. Wolff, F. Ayuk, A. Elmaagacli, H. Bertz, A. Lawitschka, M. Schleuning, R.G. Meyer, A. Gerbitz, , I. Hilgendorf, G.C. Hildebrandt, M.Edinger, S. Klein, Jörg Halter, S. Mousset, E. Holler, H. Greinix. Current practice in diagnosis and treatment of acute graft-versus-host disease – results from a survey among German-Austrian-Swiss hematopoietic stem cell transplant   centers. In: Biol Blood Marrow Transplant 2013 May;19(5):767-76.

A. Lask, E. Ophir, N. Or-Geva, A. Cohen-Fredarow, R. Afik, Y. Eidelstein, S. Reich-Zeliger, B. Nathansohn, M. Edinger, RS. Negrin, D. Hagin, Y. Reisner. A new approach for eradication of residual lymphoma cells by host nonreactive anti-third-party central memory CD8 T cells. Blood. 2013 Apr 11;121(15):3033-40

Kramer M, Heussner P, Herzberg PY, Andree H, Hilgendorf I, Leithaeuser M, Junghanss C, Freund M, Wolff D. Validation of the grip test and human activity profile for evaluation of physical performance during the intermediate phase after allogeneic hematopoietic stem cell transplantation. In: Support Care Cancer 2013 Apr;21(4):1121-9.

Pfeiffer T, Schleuning M, Mayer J, Haude KH, Tischer J, Buchholz S, Bunjes D, Bug G, Holler E, Meyer RG, Greinix H, Scheid C, Christopeit M, Schnittger S, Braess J, Schlimok G, Spiekermann K, Ganser A, Kolb HJ, Schmid C. Influence of molecular subgroups on outcome of acute myeloid leukemia with normal karyotype in 141 patients undergoing salvage allogeneic stem cell transplantation in primary induction failure or beyond first relapse. In: Haematologica 2013 Apr;98(4):518-25.

M. Sonnet, C. Baer, M. Rehli, D. Weichenhan, C. Plass. Enrichment of methylated DNA by methyl-CpG immunoprcipitation. In: Methods Mol biol.2013;971:201-12 

P. Dehan, C. Canon, G. Trooskens, M. Rehli, C. Munaut, W. Van Criekinge, P. Delvenne. Expression of type 2 orexin receptro in human endometrium and ist epigenetic silencing in endometrial cancer. In: J Clin Endocrinol Metab. 2013 Apr;98(4):1549-57. Epub 2013 Mar 12.

Hautmann AH, Wolff D, Hahn J, Edinger M, Schirmer N, Ammer J, Holler B, Landfried K, Hautmann MG, Ahrens N, Ugocsai P, Andreesen R, Holler E. Extracorporeal photopheresis in 62 patients with acute and chronic GVHD: Results of treatment with the COBE Spectra System.  In: Bone Marrow Transplant . 2013 Mar;48(3):439-45.

Demirkan A, Isaacs A, Ugocsai P, Liebisch G, Struchalin M, Rudan I, Wilson JF, Pramstaller PP, Gyllensten U, Campbell H, Schmitz G, Oostra BA, van Duijn CM. Plasma phosphatidylcholine and sphingomyelin concentrations are associated with depression and anxiety symptoms in a Dutch family-based lipidomics study. In: J Psychiatr Res 2013 Mar;47(3):357-62

Chirasani SR, Leukel P, Gottfried E, Hochrein J, Stadler K, Neumann B, Oefner PJ, Gronwald W, Bogdahn U, Hau P, Kreutz M, Grauer OM. Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model.
In: Int J Cancer. 2013 Feb 15;132(4):843-53.

Herzberg PY, Lee SJ, Heussner P, Mumm FH, Hilgendorf I, von Harsdorf S, Hemmati P, Rieger K, Greinix HT, Freund M, Holler E, Wolff D. Personality influences quality-of-life assessments in adult patients after allogeneic hematopoietic SCT: results from a joint evaluation of the prospective German Multicenter Validation Trial and the Fred Hutchinson Cancer Research Center. In: Bone Marrow Transplant. 2013 Jan;48(1):129-34.

Icheva V, Kayser S, Wolff D, Tuve S, Kyzirakos C, Bethge W, Greil J, Albert MH, Schwinger W, Nathrath M, Schumm M, Stevanovic S, Handgretinger R, Lang P, Feuchtinger T. Adoptive Transfer of Epstein-Barr Virus (EBV) Nuclear Antigen 1-Specific T Cells As Treatment for EBV Reactivation and Lymphoproliferative Disorders After Allogeneic Stem-Cell Transplantation.  In: J Clin Oncol 2013 Jan 1;31(1):39-48.

Richardson PG, Corbacioglu S, Ho VT, Kernan NA, Lehmann L, Maguire C, Maglio M, Hoyle M, Sardella M, Giralt S, Holler E, Carreras E, Niederwieser D, Soiffer R. Drug safety evaluation of defibrotide. In: Expert Opin Drug Saf . 2013 Jan;12(1):123-36.

 

Publikationen 2012 

M. Faryna, C. Konermann, S. aulmann, JL. Bermejo, M. Brugger, S. Diederichs, J. Rom, D. Weichenhan, R. Claus, M. Rehli, P. Schirmacher, HP. Sinn, C. Plass, C. Gerhauser. Genome-wide methylation Screen in low-grade breast cander identifies novel epigenetically altered genes as potential biomarkers for Tumor dignosis. in: FASEB J. 2012 Dec;26(12):4937-50. Epub 2012 Aug 28.

 

Finke J, Schmoor C, Bethge WA, Ottinger HD, Stelljes M, Zander AR, Volin L, Heim DA, Schwerdtfeger R, Kolbe K, Mayer J, Maertens JA, Linkesch W, Holler E, Koza V, Bornhäuser M, Einsele H, Bertz H, Grishina O, Socié G; ATG-Fresenius Trial Group. Prognostic factors affecting outcome after allogeneic transplantation for hematological malignancies from unrelated donors: results from a randomized trial. In: Biol Blood Marrow Transplant . 2012 Nov;18(11):1716-26.

Markó L, Paragh G, Ugocsai P, Boettcher A, Vogt T, Schling P, Balogh A, Tarabin V, Orsó E, Wikonkál N, Mandl J, Remenyik E, Schmitz G. Keratinocyte ATP binding cassette transporter expression is regulated by ultraviolet light. In: J Photochem Photobiol B . 2012 Nov 5;116:79-88.

C. Moser, P. Ruemmele, S. Gehmert, H. Schenk, M. Kreutz, ME. Mycielska, C. Hackl, A. Kroemer, AA. Schnitzbauer, O. Stoeltzing , HJ. Schlitt, EK. Geissler, SA. Lang. STAT5b as molecular target in pancreatic cancer--inhibition of tumor growth, angiogenesis, and metastases. In. Neoplasia 2012 Oct;14(10):915-25.

Bornhäuser M, Kienast J, Trenschel R, Burchert A, Hegenbart U, Stadler M, Baurmann H, Schäfer-Eckart K, Holler E, Kröger N, Schmid C, Einsele H, Kiehl MG, Hiddemann W, Schwerdtfeger R, Buchholz S, Dreger P, Neubauer A, Berdel WE, Ehninger G, Beelen DW, Schetelig J, Stelljes M. Reduced-intensity conditioning versus standard conditioning before allogeneic haemopoietic cell transplantation in patients with acute myeloid leukaemia in first complete remission: a prospective, open-label randomised phase 3 Trial. In: Lancet Oncol . 2012 Oct;13(10):1035-44.

Demirkan A, van Duijn CM, Ugocsai P, Isaacs A, Pramstaller PP, Liebisch G, Wilson JF, Johansson Å, Rudan I, Aulchenko YS, Kirichenko AV, Janssens AC, Jansen RC, Gnewuch C, Domingues FS, Pattaro C, Wild SH, Jonasson I, Polasek O, Zorkoltseva IV, Hofman A, Karssen LC, Struchalin M, Floyd J, Igl W, Biloglav Z, Broer L, Pfeufer A, Pichler I, Campbell S, Zaboli G, Kolcic I, Rivadeneira F, Huffman J, Hastie ND, Uitterlinden A, Franke L, Franklin CS, Vitart V; DIAGRAM Consortium, Nelson CP, Preuss M; CARDIoGRAM Consortium, Bis JC, O'Donnell CJ, Franceschini N; CHARGE Consortium, Witteman JC, Axenovich T, Oostra BA, Meitinger T, Hicks AA, Hayward C, Wright AF, Gyllensten U, Campbell H, Schmitz G; EUROSPAN consortium. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. In: PLoS Genet  2012;8(2):e1002490.

Klyuchnikov E, Holler E, Bornhäuser M, Kobbe G, Nagler A, Shimoni A, Könecke C, Wolschke C, Bacher U, Zander AR, Kröger N. Donor lymphocyte infusions and second transplantation as salvage treatment for relapsed myelofibrosis after reduced-intensity allografting.  In: Br J Haematol 2012 Oct;159(2):172-81.

Gökbuget N, Stanze D, Beck J, Diedrich H, Horst HA, Hüttmann A, Kobbe G, Kreuzer KA, Leimer L, Reichle A, Schaich M, Schwartz S, Serve H, Starck M, Stelljes M, Stuhlmann R, Viardot A, Wendelin K, Freund M, Hoelzer D. Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors and realization of stem cell transplantation. In: Blood.  2012 Sep 6;120(10):2032-41.

Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass CK. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. In: Cell 2012 Sep 28;151(1):138-52.

AN. Mendler, B. Hu, PU. Prinz, M. Kreutz, E. Gottfried, E. Noessner. Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation. Int J Cancer. 2012 Aug 1;131(3):633-40. Epub 2011 Oct 5.

Gottfried E, Kreutz M, Mackensen A. Tumor metabolism as modulator of immune response and tumor progression. In: Semin Cancer Biol . 2012 Aug;22(4):335-41.

Hilgendorf I, Wolff D, Nogai A, Kundt G, Hahn J, Holler E, Uharek L, Junghanss C, Leithäuser M, Thiel E, Freund M, Kahl C. Chronic Graft versus Host Disease but not the Intensity of Conditioning has Impact on Survival after Allogeneic Hematopoietic Stem Cell Transplantation for Advanced Hematological Diseases. In: Onkologie . 2012;35(9):487-92..

Kraus PD, Wolff D, Grauer O, Angstwurm K, Jarius S, Wandinger KP, Holler E, Schulte-Mattler W, Kleiter I. Muscle Cramps and Neuropathies in Patients with Allogeneic Hematopoietic Stem Cell Transplantation and Graft-versus-Host Disease. In: PLoS One . 2012;7(9):e44922..

Stemberger C, Dreher S, Tschulik C, Piossek C, Bet J, Yamamoto TN, Schiemann M, Neuenhahn M, Martin K, Schlapschy M, Skerra A, Schmidt T, Edinger M, Riddell SR, Germeroth L, Busch DH. Novel serial positive enrichment technology enables clinical multiparameter cell sorting.  In: PLoS One . 2012;7(4):e35798.

Troppmann M, Büttner R, Böwer M, Salzberger B. Smoldering myeloma presenting as progressive multifocal leukoencephalopathy: a case report. In: J Med Case Rep . 2012 Jul 2;6(1):177.

M. Grube, J. Loeffler, M. Mezger, B. Krüger, B. Echtenacher, P. Hoffmann. M. Edinger, H. Einsele, R. Andreesen. E. Holler. TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell Transplantation. Med Mycol. 2013 Nov;51(8):818-25.

Pham TH, Benner C, Lichtinger M, Schwarzfischer L, Hu Y, Andreesen R, Chen W, Rehli M. Dynamic epigenetic enhancer signatures reveal key transcription factors associated with monocytic differentiation states.  In: Blood. 2012 Jun 14;119(24):e161-71.

Walter B, Schrettenbrunner I, Vogelhuber M, Grassinger J, Bross K, Wilke J, Suedhoff T, Berand A, Wieland WF, Rogenhofer S, Andreesen R, Reichle A. Med Oncol. Pioglitazone, etoricoxib, interferon-α, and metronomic capecitabine for metastatic renal cell carcinoma: final results of a prospective phase II trial. In: Med. Oncol 2012 Jun;29(2):799-805.

Engert A, Haverkamp H, Kobe C, Markova J, Renner C, Ho A, Zijlstra J, Král Z, Fuchs M, Hallek M, Kanz L, Döhner H, Dörken B, Engel N, Topp M, Klutmann S, Amthauer H, Bockisch A, Kluge R, Kratochwil C, Schober O, Greil R, Andreesen R, Kneba M, Pfreundschuh M, Stein H, Eich HT, Müller RP, Dietlein M, Borchmann P, Diehl V; German Hodgkin Study Group; Swiss Group for Clinical Cancer Research; Arbeitsgemeinschaft Medikamentöse Tumortherapie. Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial. In: Lancet  2012 May 12;379(9828):1791-9.

Grassinger J, Williams B, Olsen GH, Haylock DN, Nilsson SK. Granulocyte colony stimulating factor expands hematopoietic stem cells within the central but not endosteal bone marrow region. In: Cytokine. 2012 May;58(2):218-25.

Troppmann M, Lippert E, Hamer OW, Kirchner G, Endlicher E. Colonic bowel wall thickening: is there a need for endoscopic evaluation?  In: Int J Colorectal Dis . 2012 May;27(5):601-4.

Hart C, Wurm S, Hafner C, Andreesen R, Grube M. [Unusual skin alterations in a 72-year-old patient with multiple myeloma.] Internist (Berl). 2012 Apr;53(4):467-73.

Krause SW, Gerken M, Andreesen R, Hofstädter F, Klinkhammer-Schalke M. Treatment of B cell lymphoma with chemotherapy plus rituximab: a survival benefit can be demonstrated in the routine data of a regional cancer registry. In: Ann Hematol. 2012 Apr;91(4):561-70.

Roll D, Ammer J, Holler B, Salzberger B, Schweiger B, Jilg W, Andreesen R, Edinger M, Wolff D, Holler E. Vaccination against pandemic H1N1 (2009) in patients after allogeneic hematopoietic stem cell transplantation: a retrospective analysis.  In: Infection. 2012 Apr;40(2):153-61.

E. Ullrich, J. Bosch, M. Aigner, S. Voelkl, I. Kroeger, P. Hoffmann, M. Kreutz, D. Dudziak, A. Gerbitz . Advances in cellular therapy: 6th international symposium on the clinical use of cellular products, March 24 and 25, 2011, Erlangen, Germany. In: Cancer Immunol Immunother. 2012 Mar;61(3):433-43.

Harris AC, Ferrara JL, Braun TM, Holler E, Teshima T, Levine JE, Choi SW, Landfried K, Akashi K, Vander Lugt M, Couriel DR, Reddy P, Paczesny S. Plasma biomarkers of lower gastrointestinal and liver acute graft-versus-host disease. In: Blood. 2012 Mar 22;119(12):2960-3.

Kaiser AD, Schuster K, Gadiot J, Borkner L, Daebritz H, Schmitt C, Andreesen R, Blank C. Reduced tumor-antigen density leads to PD-1/PD-L1-mediated impairment of partially exhausted CD8⁺ T cells.  In: Eur J Immunol . 2012 Mar;42(3):662-71.

Dietrich-Ntoukas T, Cursiefen C, Westekemper H, Eberwein P, Reinhard T, Bertz H, Nepp J, Lawitschka A, Heiligenhaus A, Seitz B, Messmer EM, Meyer-Ter-Vehn T, Basara N, Greinix H, Datiles MB, Lee SJ, Pavletic SZ, Wolff D. Diagnosis and Treatment of Ocular Chronic Graft-Versus-Host Disease: Report From the German-Austrian-Swiss Consensus Conference on Clinical Practice in Chronic GVHD. In: Cornea. 2012 Mar;31(3):299-310.

Hansmann L, Schmidl C, Kett J, Steger L, Andreesen R, Hoffmann P, Rehli M, Edinger M. Dominant Th2 Differentiation of Human Regulatory T Cells upon Loss of FOXP3 Expression. In: J Immunol. 2012 Feb1;188(3):1275-82.

Alchalby H, Yunus DR, Zabelina T, Kobbe G, Holler E, Ammer J, Prantl L, Holler B, Landfried K, Wolff D, Karrer S, Andreesen R, Holler E. Successful treatment of a refractory skin ulcer in chronic cutaneous GvHD after allogeneic HSCT with split-thickness skin allografting from the stem cell donor. In: Bone Marrow Transplant. 2012 Feb 20.

Duebgen S, Kauke T, Marschall C, Giebl A, Lison S, Hart C, Dick A, Spannagl M. Genotype and laboratory and clinical phenotypes of protein s deficiency. In: Am J Clin Pathol. 2012 Feb;137(2):178-84.

Elad S, Zeevi I, Finke J, Koldehoff M, Schwerdtfeger R, Wolff D, Mohrbacher R, Levitt M, Greinwald R, Shapira MY. Improvement in oral chronic graft-versus-host disease with the administration of effervescent tablets of topical budesonide-an open, randomized, multicenter study. In: Biol Blood Marrow Transplant. 2012 Jan;18(1):134-40.

Schmid C, Schleuning M, Tischer J, Holler E, Haude KH, Braess J, Haferlach C, Baurmann H, Oruzio D, Hahn J, Spiekermann K, Schlimok G, Schwerdtfeger R, Buechner T, Hiddemann W, Kolb HJ. Early allo-SCT for AML with a complex aberrant karyotype-results from a prospective pilot study. In: Bone Marrow Transplant. 2012 Jan;47(1):46- 53.

Byun CJ, Seo J, Jo SA, Park YJ, Klug M, Rehli M, Park MH, Jo I. DNA methylation of the 5'-untranslated region at +298 and +351 represses BACE1 expression in mouse BV-2 microglial cells. In: Biochem Biophys Res Commun. 2012 Jan;417(1):387-92.

Bornhäuser M, Schwerdtfeger R, Bethge W, Kvasnicka HM, Büsche G, Ayuk F, Bacher U, Zander AR, Kröger N. Risk models predicting survival after reduced-intensity transplantation for myelofibrosis. In: Br J Haematol. 2012 Jan 27.

Kreutz M, Karrer S, Hoffmann P, Gottfried E, Szeimies RM, Hahn J, Edinger M, Landthaler M, Andreesen R, Merad M, Holler E. Whole-body UVB irradiation during allogeneic hematopoietic cell transplantation is safe and decreases acute graft-versus-host disease. In: J Invest Dermatol. 2012 Jan;132(1):179-87.

Hausmann M, Zeitler C, Weber A, Krebs M, Kellermeier S, Rosenstiel P, de Vallière C, Kosovac K, Fried M, Holler E, Rogler G. MIP-3 α Expression in Macrophages Is NOD Dependent. In: Digestion. 2012 Jan 25;85(3):192-201.

Hilgendorf I, Mueller-Hilke B, Kundt G, Holler E, Hoffmann P, Edinger M, Freund M, Wolff D . The lack of memory B cells including T cell independent IgM(+) IgD(+) memory B cells in chronic graft-versus host disease is associated with susceptibility to infection. In: Transpl Int. 2012 Jan;25(1):87-96.

Publikationen 2011

Edinger M, Hoffmann P. Regulatory T cells in stem cell transplantation: strategies and first clinical experiences. In: Curr Opin Immunol . 2011 Oct;23(5):679-84.  

Ammer J, Hahn J, Wolff D, Holler B, Landfried K, Hautmann A, Hamer OI, Schulz Ch, Hildebrandt G, Grube M, Andreesen R, Holler E. Immunomodulation by IFN- γ in patients with resistant infections and accompanying bronchiolitis obliterans following allo-SCT. Bone Marrow Transplant. 2011 May;46(5):756-8.  

Bouazzaoui A, Spacenko E, Mueller G, Huber E, Schubert T, Holler E, Andreesen R, Hildebrandt GC. Steroid treatment alters adhesion molecule and chemokine expression in experimental acute graft-vs.-host disease of the intestinal tract. Exp Hematol. 2011 Feb;39(2):238-249.e1.

Boy S, Sauerbruch S, Kraemer M, Schormann T, Schlachetzki F, Schuierer G, Luerding R, Hennemann B , Orso E, Dabringhaus A, Winkler J, Bogdahn U; RAIS (Regeneration in Acute Ischemic Stroke) Study Group. Mobilisation of hematopoietic CD34+ precursor cells in patients with acute stroke is safe--results of an open-labeled non randomized phase I/II trial. PLoS One. 2011;6(8):e23099.

Dietrich-Ntoukas T, Cursiefen C, Westekemper H, Eberwein P, Reinhard T, Bertz H, Nepp J, Lawitschka A, Heiligenhaus A, Seitz B, Messmer EM, Meyer-Ter-Vehn T, Basara N, Greinix H, Datiles MB, Lee SJ, Pavletic SZ, Wolff D. Diagnosis and Treatment of Ocular Chronic Graft-Versus-Host Disease: Report From the German-Austrian-Swiss Consensus Conference on Clinical Practice in Chronic GVHD. Cornea. 2011 Dec 6.

Edinger M, Hoffmann P. Regulatory T cells in stem cell transplantation: strategies and first clinical experiences. Curr Opin Immunol. 2011 Oct;23(5):679-684.

Eissner G, Hartmann I, Kesikli A, Holler E, Haffner S, Sax T, Schray C, Meiser B, Reichart B. CD4+CD25+FoxP3+ regulatory T cells enhance the allogeneic activity of endothelial-specific CD8+/CD28-CTL. Int Immunol. 2011 Aug;23(8):485-92.

Ellis SL, Grassinger J, Jones A, Borg J, Camenisch T, Haylock D, Bertoncello I, Nilsson SK. The relationship between bone, hemopoietic stem cells, and vasculature. Blood. 2011 Aug 11;118(6):1516-1524.

Ferrara JL, Harris AC, Greenson JK, Braun TM, Holler E, Teshima T, Levine JE, Choi SW, Huber E, Landfried K, Akashi K, Vander Lugt M, Reddy P, Chin A, Zhang Q, Hanash S, Paczesny S. Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease. Blood. 2011 Dec 15;118(25):6702-6708.

Fragale A, Stellacci E, Ilari R, Remoli AL, Lanciotti A, Perrotti E, Shytaj I, Orsatti R, Lawrence HR, Lawrence NJ, Wu J, Rehli M, Ozato K, Battistini A. Critical role of IRF-8 in negative regulation of TLR3 expression by Src homology 2 domain-containing protein tyrosine phosphatase-2 activity in human myeloid dendritic cells. J Immunol. 2011 Feb 15;186(4):1951-62.

Gökbuget N, Basara N, Baurmann H, Beck J, Brüggemann M, Diedrich H, Güldenzoph B, Hartung G, Horst HA, Hüttmann A, Kobbe G, Naumann R, Ratei R, Reichle A, Serve H, Stelljes M, Viardot A, Wattad M, Hoelzer D. High single-drug activity of nelarabine in relapsed T-lymphoblastic leukemia/lymphoma offers curative option with subsequent stem cell transplantation. Blood. 2011 Sep 29;118(13):3504-11.

Gökbuget N, Hartog CM, Bassan R, Derigs HG, Dombret H, Greil R, Hernández-Rivas JM, Huguet F, Intermesoli T, Jourdan E, Junghanss C, Leimer L, Moreno MJ, Reichle A, Ribera J, Schmid M, Serve H, Stelljes M, Stuhlmann R, Hoelzer D; German Multicenter Study Group for Adult ALL and the European Working Group for Adult ALL. Liposomal cytarabine is effective and tolerable in the treatment of central nervous system relapse of acute lymphoblastic leukemia and very aggressive lymphoma. Haematologica. 2011 Feb;96(2):238-44.

Gottfried E, Rogenhofer S, Waibel H, Kunz-Schughart LA, Reichle A, Wehrstein M, Peuker A, Peter K, Hartmannsgruber G, Andreesen R, Kreutz M. Pioglitazone modulates tumor cell metabolism and proliferation in multicellular tumor spheroids. Cancer Chemother Pharmacol. 2011 Jan;67(1):117-26.

Grassinger J, Nilsson SK. Methods to analyze the homing efficiency and spatial distribution of hematopoietic stem and progenitor cells and their relationship to the bone marrow endosteum and vascular endothelium. Methods Mol Biol. 2011;750:197-214.

Greinix HT, Loddenkemper C, Pavletic SZ, Holler E, Socie G, Lawitschka A, Halter J, Wolff D. Diagnosis and staging of chronic graft-versus-host disease in the clinical practice. Biol Blood Marrow Transplant. 2011 Feb;17(2):167-175.

Gutiérrez A, Holler E, Zapater P, Sempere L, Jover R, Pérez-Mateo M, Schoelmerich J, Such J, Wiest R, Francés R. Antimicrobial peptide response to blood translocation of bacterial DNA in Crohn's disease is affected by NOD2/CARD15 genotype. Inflamm Bowel Dis. 2011 Aug;17(8):1641-50.

Hahn J, Stifel F, Reichle A, Holler E, Andreesen R. Clinical experience with posaconazole prophylaxis--a retrospective analysis, in a haematological unit. Mycoses. 2011 Jan;54 Suppl 1:12-6.

Hautmann AH, Elad S, Lawitschka A, Greinix H, Bertz H, Halter J, Faraci M, Hofbauer LC, Lee S, Wolff D, Holler E. Metabolic bone diseases in patients after allogeneic hematopoietic stem cell transplantation: report from the Consensus Conference on Clinical Practice in cronic graft-versus-host disease. Transpl Int. 2011 Sept;24(9):867-879.

Heesemann L, Kotz A, Echtenacher B, Broniszewska M, Routier F, Hoffmann P, Ebel F. Studies on galactofuranose-containing glycostructures of the pathogenic mold Aspergillus fumigatus. Int J Med Microbiol. 2011 Aug;301(6):523-30.

Hildebrandt GC, Fazekas T, Lawitschka A, Bertz H, Greinix H, Halter J, Pavletic SZ, Holler E, Wolff D. Diagnosis and treatment of pulmonary chronic GVHD: report from the consensus conference on clinical practice in chronic GVHD. Bone Marrow Transplant. 2011 Oct;46(10):1283-95.

Hilgendorf I, Wolff D, Gromke T, Trenschel R, Elmaagacli AH, Pichlmeier U, Junghanss C, Freund M, Beelen DW, Casper J. Retrospective analysis of treosulfan-based conditioning in comparison with standard conditioning in patients with myelodysplastic syndrome. Bone Marrow Transplant. 2011 Apr;46(4):502–09.

Hilgendorf I, Freund M, Jilg W, Einsele H, Gea-Banacloche J, Greinix H, Halter J, Lawitschka A, Wolff D, Meisel R. Vaccination of allogeneic haematopoietic stem cell transplant recipients: report from the international consensus conference on clinical practice in chronic GVHD. Vaccine. 2011 Apr 5;29(16):2825-33.

Hoetzenecker W, Echtenacher B, Guenova E, Hoetzenecker K, Woelbing F, Brück J, Teske A, Valtcheva N, Fuchs K, Kneilling M, Park JH, Kim KH, Kim KW, Hoffmann P, Krenn C, Hai T, Ghoreschi K, Biedermann T, Röcken M. ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression. Nat Med. 2011 Dec 18;18(1):128-34.

Hoffmann P, Eder R, Edinger M. Polyclonal expansion of human CD4(+)CD25(+) regulatory T cells. Methods Mol Biol. 2011;677:15-30.

Hullard-Pulstinger A, Holler E, Hahn J, Andreesen R, Krause SW. Prophylactic application of nebulized liposomal amphotericin B in hematologic patients with neutropenia. Onkologie. 2011;34(5):254-258.

Kaiser AD , Schuster K, Gadiot J, Borkner L, Daebritz H, Schmitt C, Andreesen R, Blank C. Reduced tumor-antigen density leads to PD-1/PD-L1-mediated impairment of partially exhausted CD8(+) T cells. Eur J Immunol . 2011 Dec 5. doi: 10.1002/eji.201141931.

Kawaji H, Severin J, Lizio M, Forrest AR, van Nimwegen E, Rehli M, Schroder K, Irvine K, Suzuki H, Carninci P, Hayashizaki Y, Daub CO. Update of the FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation. Nucleic Acids Res. 2011 Jan;39 D856-60.

Kittan NA, Beier F, Kurz K, Niller HH, Egger L, Jilg W, Andreesen R, Holler E, Hildebrandt GC. Isolated cerebral manifestation of Epstein-Barr virus-associated post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: a case of clinical and diagnostic challenges.  Transpl Infect Dis. 2011 Oct;13(5):524-30.

Kreyenberg H, Jarisch A, Bayer C, Schuster B, Willasch A, Strahm B, Kremens B, Gruhn B, Schrauder A, Burdach S, Führer M, Rossig C, Kabisch H, Schlegel PG, Stachel D, Beck JF, Mauz-Koerholz C, Chung TL, Holler E, Klingebiel T, Bader P. NOD2/CARD15 gene polymorphisms affect outcome in pediatric allogeneic stem cell transplantation. Blood . 2011 Jul 28;118(4):1181-4.

Krug U, Röllig C, Koschmieder A, Heinecke A, Sauerland MC, Schaich M, Thiede C, Kramer M, Braess J, Spiekermann K, Haferlach T, Haferlach C, Koschmieder S, Rohde C, Serve H, Wörmann B, Hiddemann W, Ehninger G, Berdel WE, Büchner T, Müller-Tidow C; German Acute Myeloid Leukaemia Cooperative Group; Study Alliance Leukemia Investigators.Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: a web-based application for prediction of outcomes.  Lancet 2010 Dec 11;376(9757):2000-8.

Kuhmann C, Weichenhan D, Rehli M , Plass C, Schmezer P, Popanda O. DNA methylation changes in cells regrowing after fractioned ionizing radiation. Radiother Oncol. 2011 Oct;101(1):116-21.

Landfried K , Zhu W, Waldhier MC, Schulz U, Ammer J, Holler B, Wolff D, Edinger M, Peter K, Kreutz M, Andreesen R, Oefner PJ, Holler E. Tryptophan catabolism is associated with acute GVHD after human allogeneic stem cell transplantation and indicates activation of indoleamine 2,3-dioxygenase. Blood. 2011 Dec 22;118(26):6971-6974.

Ljungman P, de la Camara R, Perez-Bercoff L, Abecasis M, Nieto Campuzano JB, Cannata-Ortiz MJ, Cordonnier C, Einsele H, Gonzalez-Vicent M, Espigado I, Halter J, Martino R, Mohty B, Sucak G, Ullmann AJ, Vázquez L, Ward KN, Engelhard D; Infectious Diseases Working Party, European Group for Blood and Marrow Transplantation; Infectious Complications Subcommittee, Spanish Group of Haematopoietic Stem-cell Transplantation. Outcome of pandemic H1N1 infections in hematopoietic stem cell transplant recipients.  Haematologica. 2011 Aug;96(8):1231-5.

Marks C, Stadler M, Häusermann P, Wolff D, Buchholz S, Stary G, Lee S, Lawitschka A, Bertz H. German-Austrian-Swiss Consensus Conference on clinical practice in chronic graft-versus-host disease (GVHD): guidance for supportive therapy of chronic cutaneous and musculoskeletal GVHD. Br J of Dermatol. 2011 Jul;165(1):18-29.

Meier JK, Wolff D, Pavletic S, Greinix H, Gosau M, Bertz H, Lee SJ, Lawitschka A, Elad S; International Consensus Conference on Clinical Practice in cGVHD. Oral chronic graft-versus-host disease: report from the International Consensus Conference on clinical practice in cGVHD. Clin Oral Investig. 2011 Apr;15(2):127-139.

Mendler AN, Hu B, Prinz PU, Kreutz M , Gottfried E, Noessner E.   Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation. Int J Cancer. 2011 Sep 2.

Plander M, Ugocsai P, Seegers S, Orsó E, Reichle A, Schmitz G, Hofstädter F, Brockhoff G. Chronic lymphocytic leukemia cells induce anti-apoptotic effects of bone marrow stroma. Ann Hematol. 2011 Dec;90(12):1381-90.

Reinhold SW, Reichle A, Leiminger S, Bergler T, Hoffmann U, Krüger B, Banas B, Krämer BK. Renal function during rofecoxib therapy in patients with metastatic cancer: retrospective analysis of a prospective phase II trial. BMC Res Notes. 2011 Jan 5;4:2.

Roll D, Ammer J, Holler B, Salzberger B, Schweiger B, Jilg W, Andreesen R, Edinger M, Wolff D, Holler E. Vaccination against pandemic H1N1 (2009) in patients after allogeneic hematopoietic stem cell transplantation: a retrospective analysis. Infection. 2011 Oct 29.

Schäffler A, Hamer OW, Dickopf J, Goetz A, Landfried K, Voelk M, Herfarth H, Kopp A, Buechler C, Schölmerich J, Brünnler T. Admission visfatin levels predict pancreatic and peripancreatic necrosis in acute pancreatitis and correlate with clinical severity. Am J Gastroenterol. 2011 May;106(5):957-67.

Schmidl C, Hansmann L, Andreesen R, Edinger M, Hoffmann P, Rehli M. Epigenetic reprogramming of the RORC locus during in vitro expansion is a distinctive feature of human memory but not naïve Treg. Eur J Immunol. 2011 May;41(5):1491-1498.

Schreyer AG, Landfried K, Jung EM, da Silva NP, Poschenrieder F, Dornia C, Wiggermann P, Dendl LM, Holler E, Stroszczynski C, Friedrich C. Contrast-enhanced ultrasound for differential diagnosis of suspected GvHD in patients after allogeneic transplantation. Clin Hemorheol Microcirc. 2011 Jan 1;49(1):129-36.

Schreyer AG, Landfried K , Zorger N, Hoffstetter P, Ammer J, Fellner C, Friedrich C, Andreesen R, Holler E, Jung EM. Transmural penetration of intravenously applied microbubbles during contrast-enhanced ultrasound as a new diagnostic feature in patients with GVHD of the bowel. Bone Marrow Transplant. 2011 Jul;46(7):1006-1011.

Shao Z, Schäffler A, Hamer O, Dickopf J, Goetz A, Landfried K, Voelk M, Kopp A, Herfarth H, Karrasch T, Brünnler T, Koh LK, Buechler C, Schwarz H. Admission levels of soluble CD137 are increased in patients with acute pancreatitis and are associated with subsequent complications. Exp Mol Pathol. 2011 Sep 22;92(1):1-6.

Singer K, Kastenberger M, Gottfried E, Hammerschmied CG, Büttner M, Aigner M, Seliger B, Walter B, Schlösser H, Hartmann A, Andreesen R, Mackensen A, Kreutz M. Warburg phenotype in renal cell carcinoma: high expression of glucose-transporter 1 (GLUT-1) correlates with low CD8+ T-cell infiltration in the tumor. Int J Cancer. 2011 May 1;128(9):2085-95.

Singer K, Gottfried E, Kreutz M, Mackensen A. Suppression of T‑cell responses by tumor metabolites. Cancer Immunol Immunother. 2011 Mar;60(3):425-31.

Socié G, Schmoor C, Bethge WA, Ottinger HD, Stelljes M, Zander AR, Volin L, Ruutu T, Heim DA, Schwerdtfeger R, Kolbe K, Mayer J, Maertens JA, Linkesch W, Holler E, Koza V, Bornhäuser M, Einsele H, Kolb HJ, Bertz H, Egger M, Grishina O, Finke J; ATG-Fresenius Trial Group. Chronic graft-versus-host disease: long-term results from a randomized trial on graft-versus-host disease prophylaxis with or without anti-T-cell globulin ATG-Fresenius. Blood. 2011 Jun 9;117(23):6375-82.

Stelljes M, Beelen DW, Braess J, Sauerland MC, Heinecke A, Berning B, Kolb HJ, Holler E, Schwerdtfeger R, Arnold R, Spiekermann K, Müller-Tidow C, Serve HL, Silling G, Hiddemann W, Berdel WE, Buchner T, Kienast J; German AML Cooperative Group (AMLCG). Allogeneic transplantation as post-remission therapy for cytogenetically high-risk acute myeloid leukemia: landmark analysis from a single prospective multicenter trial. Haematologica. 2011 Jul;96(7):972-9.

Thiel U, Wawer A, Wolf P, Badoglio M, Santucci A, Klingebiel T, Basu O, Borkhardt A, Laws HJ, Kodera Y, Yoshimi A, Peters C, Ladenstein R, Pession A, Prete A, Urban EC, Schwinger W, Bordigoni P, Salmon A, Diaz MA, Afanasyev B, Lisukov I, Morozova E, Toren A, Bielorai B, Korsakas J, Fagioli F, Caselli D, Ehninger G, Gruhn B, Dirksen U, Abdel-Rahman F, Aglietta M, Mastrodicasa E, Torrent M, Corradini P, Demeocq F, Dini G, Dreger P, Eyrich M, Gozdzik J, Guilhot F, Holler E , Koscielniak E, Messina C, Nachbaur D, Sabbatini R, Oldani E, Ottinger H, Ozsahin H, Schots R, Siena S, Stein J, Sufliarska S, Unal A, Ussowicz M, Schneider P, Woessmann W, Jürgens H, Bregni M, Burdach S; Solid Tumor Working Party (STWP) and the Pediatric DiseaseWorking Party (PDWP) of the European Group for Blood and Marrow Transplantation (EBMT); Asia Pacific Blood and Marrow Transplantation (APBMT); Pediatric Registry for Stem Cell Transplantations (PRST); MetaEICESS Study Group. No improvement of survival with reduced- versus high-intensity conditioning for allogeneic stem cell transplants in Ewing tumor patients. Ann Oncol . 2011 Jul;22(7):1614-21.

Travnik R, Beckers M, Wolff D, Holler E, Landthaler M, Karrer S. Graft-versus-Host Disease (GvHD) - an update: Part 1:Pathophysiology, clinical features and classification of GvHD. Hautarzt. 2011 Feb;62(2):139-54.

Travnik R, Beckers M, Wolff D, Holler E, Landthaler M, Karrer S. Graft-versus-Host Disease (GvHD) - an update: Part 2: Prognosis and therapy of GvHD. Hautarzt. 2011 Mar;62(3):229-237.

Ullrich E , Bosch J, Aigner M, Voelkl S, Kroeger I, Hoffmann P, Kreutz M, Dudziak D, Gerbitz A. Advances in cellular therapy: 6th international symposium on the clinical use of cellular products, March 24 and 25, 2011, Erlangen, Germany. Cancer Immunol Immunother . 2011 Dec 27.

Walter B, Schrettenbrunner I, Vogelhuber M, Grassinger J, Bross K, Wilke J, Suedhoff T, Berand A, Wieland WF, Rogenhofer S, Andreesen R, Reichle A. Pioglitazone, etoricoxib, interferon- α , and metronomic capecitabine for metastatic renal cell carcinoma: final results of a prospective phase II trial. Med Oncol. 2011 May 24.

Wiese CH, Duttge G, Taghavi M, Lassen CL, Meyer N, Andreesen R, Graf BM, Pfirstinger J . Preventive crisis management in general outpatient palliative care - prospectively cross-sectional study of General Practitioners in Eastern Bavaria. Dtsch Med Wochenschr. 2011 Nov;136(45):2302-7.

Wolff D, Schleuning M, von Harsdorf S, Bacher U, Gerbitz A, Stadler M, Ayuk F, Kiani A, Schwerdtfeger R, Vogelsang GB, Kobbe G, Gramatzki M, Lawitschka A, Mohty M, Pavletic SZ, Greinix H, Holler E. Consensus Conference on Clinical Practice in Chronic GVHD: Second-Line Treatment of Chronic Graft-versus-Host Disease. Biol Blood Marrow Transplant. 2011 Jan;17(1):1-17.

Wolff D, Bertz H, Greinix H, Lawitschka A, Halter J, Holler E. The treatment of chronic graft-versus-host disease: consensus recommendations of experts from Germany, Austria, and Switzerland. Dtsch Arztebl Int. 2011 Oct;108(43):732-40.

Zeiser R, Penack O, Holler E, Idzko M. Danger signals activating innate immunity in graft-versus-host disease. J Mol Med (Berl). 2011 Sep;89(9):833-45.

Zhu W, Stevens AP, Dettmer K, Gottfried E, Hoves S, Kreutz M , Holler E, Canelas AB, Kema I, Oefner PJ. Quantitative profiling of tryptophan metabolites in serum, urine, and cell culture supernatants by liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem. 2011 Dec;401(10):3249-61.

 
Publikationen 2010

Alchalby H, Badbaran A, Zabelina T, Kobbe G, Hahn J, Wolff D, Bornhäuser M, Thiede C, Baurmann H, Bethge W, Hildebrandt Y, Bacher U, Fehse B, Zander AR, Kröger N. Impact of JAK2V617F mutation status, allele burden, and clearance after allogeneic stem cell transplantation for myelofibrosis. Blood . 2010 Nov 4;116(18):3572-81. Epub 2010 May 20.

Beier F, Beier CP, Aschenbrenner I, Hildebrandt GC, Brümmendorf TH, Beier D. Identification of CD133(-)/Telomerase (low) Progenitor Cells in Glioblastoma-Derived Cancer Stem Cell Lines.  Cell Mol Neurobiol. 2010 Nov 17.

Beier F, Kittan N, Holzmann T, Schardt K, Andreesen R, Holler E, Hildebrandt GC. Successful treatment of Scedosporium apiospermum soft tissue abscess with caspofungin and voriconazole in a severely immunocompromised patient with acute myeloid leukemia. Transpl Infect Dis . 2010 Dec;12(6):538-42. doi: 10.1111/j.1399-3062.2010.00537.x.

Beier F, Moleda L, Guralnik V, Hahn P, Schardt K, Andreesen R, Schölmerich J, Schäffler A. Papillary thyroid cancer associated with syndrome of inappropriate antidiuresis: a case report. J Med Case Reports . 2010 Apr 21;4:110.

Borkner L, Kaiser A, van de Kasteele W, Andreesen R, Mackensen A, Haanen JB, Schumacher TN, Blank C. RNA interference targeting programmed death receptor-1 improves immune functions of tumor-specific T cells. Cancer Immunol Immunother . 2010 Aug;59(8):1173-83. Epub 2010 Mar 27.

Casper J, Wolff D, Knauf W, Blau IW, Ruutu T, Volin L, Wandt H, Schäfer-Eckart K, Holowiecki J, Giebel S, Aschan J, Zander AR, Kröger N, Hilgendorf I, Baumgart J, Mylius HA, Pichlmeier U, Freund M. Allogeneic hematopoietic stem-cell transplantation in patients with hematologic malignancies after dose-escalated treosulfan/fludarabine conditioning. J Clin Oncol . 2010 Jul 10;28(20):3344-51. Epub 2010 May 24. Erratum in: J Clin Oncol. 2010 Aug 10;28(23):3797.

Dickinson AM, Pearce KF, Norden J, O'Brien SG, Holler E, Bickeböller H, Balavarca Y, Rocha V, Kolb HJ, Hromadnikova I, Sedlacek P, Niederwieser D, Brand R, Ruutu T, Apperley J, Szydlo R, Goulmy E, Siegert W, de Witte T, Gratwohl A. Impact of genomic risk factors on outcome after hematopoietic stem cell transplantation for patients with chronic myeloid leukemia. Haematologica . 2010 Mar 19. [Epub ahead of print]

Dietl K, Renner K, Dettmer K, Timischl B, Eberhart K, Dorn C, Hellerbrand C, Kastenberger M, Kunz-Schughart LA, Oefner PJ, Andreesen R, Gottfried E, Kreutz MP. Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes. J Immunol . 2010 Feb 1;184(3):1200-9. Epub 2009 Dec 21.

Dreger P, Döhner H, Ritgen M, Böttcher S, Busch R, Dietrich S, Bunjes D, Cohen S, Schubert J, Hegenbart U, Beelen D, Zeis M, Stadler M, Hasenkamp J, Uharek L, Scheid C, Humpe A, Zenz T, Winkler D, Hallek M, Kneba M, Schmitz N, Stilgenbauer S; German CLL Study Group. Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial. Blood . 2010 Oct 7;116(14):2438-47. Epub 2010 Jul 1.

Engert A , Josting A , Haverkamp H , Villalobos M , Lohri A , Sökler M , Zijlstra J , Sturm I , Topp MS , Rank A , Zenz T , Vogelhuber M , Nogova L , Borchmann P , Fuchs M , Flechtner HH , Diehl V . Epoetin alfa in patients with advanced-stage Hodgkin's lymphoma: results of the randomized placebo-controlled GHSG HD15EPO trial. J Clin Oncol. 2010 May 1;28(13):2239-45. Epub 2010 Apr 5.

El Chartouni C, Rehli M. Comprehensive analysis of TLR4-induced transcriptional responses in interleukin 4-primed mouse macrophages. Immunobiology . 2010 Sep-Oct;215(9-10):780-7. Epub 2010 Jun 4.

El Chartouni C, Schwarzfischer L, Rehli M. Interleukin-4 induced interferon regulatory factor (Irf) 4 participates in the regulation of alternative macrophage priming. Immunobiology . 2010 Sep-Oct;215(9-10):821-5. Epub 2010 Jun 4.

Gebhard C, Benner C, Ehrich M, Schwarzfischer L, Schilling E, Klug M, Dietmaier W, Thiede C, Holler E, Andreesen R, Rehli M. General transcription factor binding at CpG islands in normal cells correlates with resistance to de novo DNA methylation in cancer cells. Cancer Res . 2010 Feb 15;70(4):1398-407. Epub 2010 Feb 9.

Grassinger J, Haylock DN, Williams B, Olsen GH, Nilsson SK. Phenotypically identical hemopoietic stem cells isolated from different regions of bone marrow have different biologic potential. Blood . 2010 Oct 28;116(17):3185-96. Epub 2010 Jul 14.

Grauer O, Wolff D, Bertz H, Greinix H, Kühl JS, Lawitschka A, Lee SJ, Pavletic SZ, Holler E, Kleiter I. Neurological manifestations of chronic graft-versus-host disease after allogeneic haematopoietic stem cell transplantation: report from the Consensus Conference on Clinical Practice in chronic graft-versus-host disease. Brain . 2010 Oct;133(10):2852-65. Epub 2010 Sep 15. Review.

Herzberg PY, Heussner P, Mumm FH, Horak M, Hilgendorf I, von Harsdorf S, Hemmati P, Rieger K, Greinix H, Freund M, Lee SJ, Holler E, Wolff D. Validation of the human activity profile questionnaire in patients after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant . 2010 Dec;16(12):1707-17. Epub 2010 Jun 9.

G. C. Hildebrandt, T. Fazekas, A. Lawitschka, H. Bertz, H. Greinix, J. Halter, S. Z. Pavletic, E. Holler, D. Wolff. Diagnosis and Treatment of Pulmonary Chronic Graft-versus-Host Disease: Report from the International Consensus Conference on Clinical Practice in chronic GVHD. Bone Marrow Transplantation,   in press 2010

Hofmann C, Dunger N, Grunwald N, Hämmerling GJ, Hoffmann P, Schölmerich J, Falk W, Obermeier F. T cell-dependent protective effects of CpG motifs of bacterial DNA in experimental colitis are mediated by CD11c+ dendritic cells. Gut . 2010 Oct;59(10):1347-54. Epub 2010 Aug 23.

M.C. Holtfreter, M. Loebermann, E.Frei, D. Riebold, D. Wolff, G. Hartung, R. Kinzelbach, E..C. Reisinger. Schistosomula, pre-adults and adults of Schistosoma mansoni ingest fluorescence-labeled albumin in vitro and in vivo: implication for drug-targeting model. Parasitology, 2010, 11: 1645 - 1652

Holler E, Landfried K, Meier J, Hausmann M, Rogler G. The role of bacteria and pattern recognition receptors in GVHD. Int J Inflam . 2010 Oct 31;2010:814326.

Klug M, Heinz S, Gebhard C, Schwarzfischer L, Krause SW, Andreesen R, Rehli M. Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels. Genome Biol . 2010;11(6):R63. Epub 2010 Jun 18.

Kosovac K, Brenmoehl J, Holler E, Falk W, Schoelmerich J, Hausmann M, Rogler G. Association of the NOD2 genotype with bacterial translocation via altered cell-cell contacts in Crohn's disease patients. Inflamm Bowel Dis . 2010 Mar 15. [Epub ahead of print]

Krug U, Röllig C, Koschmieder A, Heinecke A, Sauerland MC, Schaich M, Thiede C, Kramer M, Braess J, Spiekermann K, Haferlach T, Haferlach C, Koschmieder S, Rohde C, Serve H, Wörmann B, Hiddemann W, Ehninger G, Berdel WE, Büchner T, Müller-Tidow C; Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: a web-based application for prediction of outcomes. German Acute Myeloid Leukaemia Cooperative Group; Study Alliance Leukemia Investigators. Lancet 2010 Dec 11;376(9757):2000-8.

Ksiazkiewicz M, Gottfried E, Kreutz M, Mack M, Hofstaedter F, Kunz-Schughart LA. Importance of CCL2-CCR2A/2B signaling for monocyte migration into spheroids of breast cancer-derived fibroblasts. Immunobiology . 2010 Sep-Oct;215(9-10):737-47. Epub 2010 Jun 4.

Kubosaki A, Lindgren G, Tagami M, Simon C, Tomaru Y, Miura H, Suzuki T, Arner E, Forrest AR, Irvine KM, Schroder K, Hasegawa Y, Kanamori-Katayama M, Rehli M, Hume DA, Kawai J, Suzuki M, Suzuki H, Hayashizaki Y. The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells. Mol Immunol . 2010 Aug;47(14):2295-302. Epub 2010 Jun 22.

Landfried K, Bataille F, Rogler G, Brenmoehl J, Kosovac K, Wolff D, Hilgendorf I, Hahn J, Edinger M, Hoffmann P, Obermeier F, Schoelmerich J, Andreesen R, Holler E. Recipient NOD2/CARD15 status affects cellular infiltrates in human intestinal graft-versus-host disease. Clin Exp Immunol . 2010 Jan;159(1):87-92. Epub 2009 Nov 11.

Holler E, Landfried K, Meier J, Hausmann M, Rogler G.The role of bacteria and pattern recognition receptors in GVHD.  Int J Inflam . 2010 Oct 31;2010:814326.

Langmann T, Rehli M. Immunobiology. Editorial. Immunobiology . 2010 Sep-Oct;215(9-10):673. No abstract available.

Meier JK, Wolff D, Pavletic S, Greinix H, Gosau M, Bertz H, Lee SJ, Lawitschka A, Elad S. Oral chronic graft-versus-host disease: report from the International Consensus Conference on clinical practice in cGVHD. Clin Oral Investig . 2010 Sep 22. [Epub ahead of print]

Müller-Tidow C, Klein HU, Hascher A, Isken F, Tickenbrock L, Thoennissen N, Agrawal-Singh S, Tschanter P, Disselhoff C, Wang Y, Becker A, Thiede C, Ehninger G, zur Stadt U, Koschmieder S, Seidl M, Müller FU, Schmitz W, Schlenke P, McClelland M, Berdel WE, Dugas M, Serve H; Study Alliance Leukemia. Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia. Blood. 2010 Nov 4;116(18):3564-71. 

Penack O, Holler E, van den Brink MR. Graft-versus-host disease: regulation by microbe-associated molecules and innate immune receptors. Blood . 2010 Mar 11;115(10):1865-72. Epub 2009 Dec 30.

Saussele S, Lauseker M, Gratwohl A, Beelen DW, Bunjes D, Schwerdtfeger R, Kolb HJ, Ho AD, Falge C, Holler E, Schlimok G, Zander AR, Arnold R, Kanz L, Dengler R, Haferlach C, Schlegelberger B, Pfirrmann M, Müller MC, Schnittger S, Leitner A, Pletsch N, Hochhaus A, Hasford J, Hehlmann R; German CML Study Group. Allogeneic hematopoietic stem cell transplantation (allo SCT) for chronic myeloid leukemia in the imatinib era: evaluation of its impact within a subgroup of the randomized German CML Study IV. Blood . 2010 Mar 11;115(10):1880-5. Epub 2009 Nov 18.

Sparmann G, Kruse ML, Hofmeister-Mielke N, Koczan D, Jaster R, Liebe S, Wolff D, Emmrich J. Bone marrow-derived pancreatic stellate cells in rats. Cell Res . 2010 Mar;20(3):288-98. Epub 2010 Jan 26.

Schulz U, Kreutz M, Multhoff G, Stoelcker B, Köhler M, Andreesen R, Holler E. Interleukin-10 promotes NK cell killing of autologous macrophages by stimulating expression of NKG2D ligands. Scand J Immunol . 2010 Oct;72(4):319-31. doi: 10.1111/j.1365-3083.2010.02435.x.

Ullrich E, Bosch J, Aigner M, Völkl S, Dudziak D, Spriewald B, Schuler G, Andreesen R, Mackensen A. Advances in cellular therapy: 5th International Symposium on the clinical use of cellular products, 19 and 20 March 2009, Nürnberg, Germany. Cancer Immunol Immunother . 2010 Nov;59(11):1745-56. Epub 2009 Oct 28. No abstract available.

Walter B, Rogenhofer S, Vogelhuber M, Berand A, Wieland WF, Andreesen R, Reichle A. Modular therapy approach in metastatic castration-refractory prostate cancer. World J Urol . 2010 Dec;28(6):745-50. Epub 2010 May 19.

Wolff D, Gerbitz A, Ayuk F, Kiani A, Hildebrandt GC, Vogelsang GB, Elad S, Lawitschka A, Socie G, Pavletic SZ, Holler E, Greinix H. Consensus conference on clinical practice in chronic graft-versus-host disease (GVHD): first-line and topical treatment of chronic GVHD. Biol Blood Marrow Transplant . 2010 Dec;16(12):1611-28. Epub 2010 Jun 25.

Yokota S, Okabayashi T, Rehli M, Fujii N, Amano K. Helicobacter pylori lipopolysaccharides upregulate toll-like receptor 4 expression and proliferation of gastric epithelial cells via the MEK1/2-ERK1/2 mitogen-activated protein kinase pathway. Infect Immun . 2010 Jan;78(1):468-76. Epub 2009 Oct 26.

 

Publikationen 2009

Abrams B, Diwu Z, Guryev O, Aleshkov S, Hingorani R, Edinger M, Lee R, Link J, Dubrovsky T. 3-Carboxy-6-chloro-7-hydroxycoumarin: A highly fluorescent, water-soluble violet-excitabledye for cell analysis. Anal Biochem. 2009 Mar 15;386(2):262-269.

Amann T, Maegdefrau U, Hartmann A, Agaimy A, Marienhagen J, Weiss TS, Stoeltzing O, Warnecke C, Schölmerich J, Oefner PJ, Kreutz M, Bosserhoff AK, Hellerbrand C. GLUT1 Expression Is Increased in Hepatocellular Carcinoma and Promotes Tumorigenesis. Am J Pathol. 2009 Apr;174(4):1544-52. Epub 2009 Mar 12.

Bouazzaoui A, Spacenko E, Mueller G, Miklos S, Huber E, Holler E, Andreesen R, Hildebrandt GC. Chemokine and chemokine receptor expression analysis in target organs of acute graft-versus-host disease. Genes Immun. 2009 Dec;10(8):687-701. Epub 2009 Jul 2.

Braess J, Spiekermann K, Staib P, Gruneisen A, Wormann B, Ludwig WD, Serve H, Reichle A, Peceny R, Oruzio D, Schmid C, Schiel X, Hentrich M, Sauerland C, Unterhalt M, Fiegl M, Kern W, Buske C, Bohlander S, Heinecke A, Baurmann H, Beelen DW, Berdel WE, Buchner T, Hiddemann W. Dose-dense induction with sequential-high-dose cytarabine and mitoxantone (S-HAM) and pegfilgrastim results in a high efficacy and a short duration of critical neutropenia in de-novo acute myeloid leukemia - a pilot study of the AML-CG. Blood. 2009 Apr 23;113(17):3903-10. Epub 2009 Jan 8.

Büchner T, Berdel WE, Haferlach C, Haferlach T, Schnittger S, Müller-Tidow C, Braess J, Spiekermann K, Kienast J, Staib P, Grüneisen A, Kern W, Reichle A, Maschmeyer G, Aul C, Lengfelder E, Sauerland MC, Heinecke A, Wörmann B, Hiddemann W. Age-related risk profile and chemotherapy dose response in acute myeloid leukemia: a study by the German Acute Myeloid Leukemia Cooperative Group. J Clin Oncol . 2009 Jan 1;27(1):61-9. Epub 2008 Dec 1.

Bundscherer A, Reichle A, Hafner C, Meyer S, Vogt T. Targeting the tumor stroma with peroxisome proliferator activated receptor (PPAR) agonists. Anticancer Agents Med Chem . 2009 Sep;9(7):816-21. Epub 2009 Sep 1. Review.

Chang YY, Greinix HT, Dickinson AM, Wolff D, Jackson GH, Andreesen R, Holler E, Hildebrandt GC. G to C transition at position -173 of MIF gene of the recipient is associated with reduced relapse rates after allogeneic stem cell transplantation. Cytokine . 2009 Dec;48(3):218-25. Epub 2009 Aug 31.

Dietl K, Renner K, Dettmer K, Timischl B, Eberhart K, Dorn C, Hellerbrand C, Kastenberger M, Kunz-Schughart LA, Oefner PJ, Andreesen R, Gottfried E, Kreutz MP. Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes. J Immunol . 2009 Dec 21. [Epub ahead of print]

Eberhart K, Renner K, Ritter I, Kastenberger M, Singer K, Hellerbrand C, Kreutz M, Kofler R, Oefner PJ. Low doses of 2-deoxy-glucose sensitize acute lymphoblastic leukemia cells to glucocorticoid-induced apoptosis. Leukemia . 2009 Nov;23(11):2167-70. Epub 2009 Aug 6. No abstract available.

Edinger M. Regulatory T cells for the prevention of graft-versus-host disease: Professionals defeat amateurs. Eur J Immunol . 2009 Oct 28;39(11):2966-2968. [Epub ahead of print]

El Chartouni C, Benner C, Eigner M, Lichtinger M, Rehli M. Transcriptional effects of Colony-stimulating factor-1 in mouse macrophages. Immunobiology . 2009 Sep 14. [Epub ahead of print]

FANTOM Consortium, Suzuki H, Forrest AR, van Nimwegen E, Daub CO, Balwierz PJ, Irvine KM, Lassmann T, Ravasi T, Hasegawa Y, de Hoon MJ, Katayama S, Schroder K, Carninci P, Tomaru Y, Kanamori-Katayama M, Kubosaki A, Akalin A, Ando Y, Arner E, Asada M, Asahara H, Bailey T, Bajic VB, Bauer D, Beckhouse AG, Bertin N, Björkegren J, Brombacher F, Bulger E, Chalk AM, Chiba J, Cloonan N, Dawe A, Dostie J, Engström PG, Essack M, Faulkner GJ, Fink JL, Fredman D, Fujimori K, Furuno M, Gojobori T, Gough J, Grimmond SM, Gustafsson M, Hashimoto M, Hashimoto T, Hatakeyama M, Heinzel S, Hide W, Hofmann O, Hörnquist M, Huminiecki L, Ikeo K, Imamoto N, Inoue S, Inoue Y, Ishihara R, Iwayanagi T, Jacobsen A, Kaur M, Kawaji H, Kerr MC, Kimura R, Kimura S, Kimura Y, Kitano H, Koga H, Kojima T, Kondo S, Konno T, Krogh A, Kruger A, Kumar A, Lenhard B, Lennartsson A, Lindow M, Lizio M, Macpherson C, Maeda N, Maher CA, Maqungo M, Mar J, Matigian NA, Matsuda H, Mattick JS, Meier S, Miyamoto S, Miyamoto-Sato E, Nakabayashi K, Nakachi Y, Nakano M, Nygaard S, Okayama T, Okazaki Y, Okuda-Yabukami H, Orlando V, Otomo J, Pachkov M, Petrovsky N, Plessy C, Quackenbush J, Radovanovic A, Rehli M, Saito R, Sandelin A, Schmeier S, Schönbach C, Schwartz AS, Semple CA, Sera M, Severin J, Shirahige K, Simons C, St Laurent G, Suzuki M, Suzuki T, Sweet MJ, Taft RJ, Takeda S, Takenaka Y, Tan K, Taylor MS, Teasdale RD, Tegnér J, Teichmann S, Valen E, Wahlestedt C, Waki K, Waterhouse A, Wells CA, Winther O, Wu L, Yamaguchi K, Yanagawa H, Yasuda J, Zavolan M, Hume DA; Riken Omics Science Center, Arakawa T, Fukuda S, Imamura K, Kai C, Kaiho A, Kawashima T, Kawazu C, Kitazume Y, Kojima M, Miura H, Murakami K, Murata M, Ninomiya N, Nishiyori H, Noma S, Ogawa C, Sano T, Simon C, Tagami M, Takahashi Y, Kawai J, Hayashizaki Y. The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet . 2009 May;41(5):553-62. Epub 2009 Apr 19.

Ferrara JL, Levine JE, Reddy P, Holler E. Graft-versus-host disease. Lancet . 2009 May 2;373(9674):1550-61. Epub 2009 Mar 11. Review.

Finke J, Bethge WA, Schmoor C, Ottinger HD, Stelljes M, Zander AR, Volin L, Ruutu T, Heim DA, Schwerdtfeger R, Kolbe K, Mayer J, Maertens JA, Linkesch W, Holler E, Koza V, Bornhäuser M, Einsele H, Kolb HJ, Bertz H, Egger M, Grishina O, Socié G; ATG-Fresenius Trial Group. Standard graft-versus-host disease prophylaxis with or without anti-T-cell globulin in haematopoietic cell transplantation from matched unrelated donors: a randomised, open-label, multicentre phase 3 trial. Lancet Oncol . 2009 Sep;10(9):855-64. Epub 2009 Aug 18.

Fowler D, Hoffmann P, Edinger M. Functionally defined T cell subsets in transplantation biology and therapy: regulatory T cells and th2 cells. Cancer Treat Res . 2009;144:1-32. No abstract available.

Hart C, Grassinger J, Andreesen R, Hennemann B. EPO in combination with G-CSF improves mobilization effectiveness after chemotherapy with ifosfamide, epirubicin and etoposide and reduces costs during mobilization and transplantation of autologous hematopoietic progenitor cells. Bone Marrow Transplant . 2009 Feb;43(3):197-206. Epub 2008 Sep 22

Hoffmann P, Boeld TJ, Eder R, Huehn J, Floess S, Wieczorek G, Olek S, Dietmaier W, Andreesen R, Edinger M. Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation. Eur J Immunol . 2009 Apr;39(4):1088-97.

Holler E, Kolb HJ, Greinix H, Perrotin D, Campilho F, Aversa F, Gil L, Cornelissen J, Varanese L, Schacht A, Friese A, Rustige J. Bleeding events and mortality in SCT patients: a retrospective study of hematopoietic SCT patients with organ dysfunctions due to severe sepsis or GVHD. Bone Marrow Transplant 2009 Mar;43(6):491-7. Epub 2008 Dec 15.

Korb J, Weil T, Hoffmann K, Foster KR, Rehli M. A gene necessary for reproductive suppression in termites. Science . 2009 May 8;324(5928):758.

Kröger N, Holler E, Kobbe G, Bornhäuser M, Schwerdtfeger R, Baurmann H, Nagler A, Bethge W, Stelljes M, Uharek L, Wandt H, Burchert A, Corradini P, Schubert J, Kaufmann M, Dreger P, Wulf GG, Einsele H, Zabelina T, Kvasnicka HM, Thiele J, Brand R, Zander AR, Niederwieser D, de Witte TM. Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. Blood . 2009 Dec 17;114(26):5264-70. Epub 2009 Oct 7.

Landfried K, Bataille F, Rogler G, Brenmoehl J, Kosovac K, Wolff D, Hilgendorf I, Hahn J, Edinger M, Hoffmann P, Obermeier F, Schoelmerich J, Andreesen R, Holler E. Recipient NOD2/CARD15 status affects cellular infiltrates in human intestinal graft-versus-host disease. Clin Exp Immunol . 2009 Nov;159(1):87-92. Epub 2009 Nov 11.

Landfried K, Wolff D, Holler E. Pathophysiology and management of graft-versus-host disease in the era of reduced-intensity conditioning. Curr Opin Oncol . 2009 Jun;21 Suppl 1:S39-41. Review.

Leithauser M, Kahl C, Aepinus C, Prall F, Maruschke M, Riemer H, Wolff D, Jost K, Hilgendorf I, Freund M, Junghanss C. Invasive zygomycosis in patients with graft-versus-host disease after allogeneic stem cell transplantation. Transpl Infect Dis 2010, 12: 251-257

Lengfelder E, Haferlach C, Saussele S, Haferlach T, Schultheis B, Schnittger S, Ludwig WD, Staib P, Aul C, Grüneisen A, Kern W, Reichle A, Serve H, Berdel WE, Braess J, Spiekermann K, Wörmann B, Sauerland MC, Heinecke A, Hiddemann W, Hehlmann R, Büchner T; German AML Cooperative Group. High dose ara-C in the treatment of newly diagnosed acute promyelocytic leukemia: long-term results of the German AMLCG. Leukemia . 2009 Dec;23(12):2248-58. Epub 2009 Sep 10.

Meyer S, Vogt T, Landthaler M, Berand A, Reichle A, Bataille F, Marx AH, Menz A, Hartmann A, Kunz-Schughart LA, Wild PJ. Cyclooxygenase 2 (COX2) and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Are Stage-Dependent Prognostic Markers of Malignant Melanoma. PPAR Res . 2009;2009:848645. Epub 2009 Jul 20.

Miklos S, Mueller G, Chang Y, Bouazzaoui A, Spacenko E, Schubert TE, Grainger DJ, Holler E, Andreesen R, Hildebrandt GC. Preventive usage of broad spectrum chemokine inhibitor NR58-3.14.3 reduces the severity of pulmonary and hepatic graft-versus-host disease. Int J Hematol . 2009 Apr;89(3):383-97. Epub 2009 Mar 14.

Mori A, Moser C, Lang SA, Hackl C, Gottfried E, Kreutz M, Schlitt HJ, Geissler EK, Stoeltzing O. Up-regulation of Krüppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor-1alpha. Mol Cancer Res . 2009 Aug;7(8):1390-8. Epub 2009 Aug 11.

Mueller DW, Rehli M, Bosserhoff AK. miRNA Expression Profiling in Melanocytes and Melanoma Cell Lines Reveals miRNAs Associated with Formation and Progression of Malignant Melanoma. J Invest Dermatol . 2009 Jul;129(7):1740-51. Epub 2009 Feb 12.

Palomo M, Diaz-Ricart M, Carbo C, Rovira M, Fernandez-Aviles F, Escolar G, Eissner G, Holler E, Carreras E. The release of soluble factors contributing to endothelial activation and damage after hematopoietic stem cell transplantation is not limited to the allogeneic setting and involves several pathogenic mechanisms. Biol Blood Marrow Transplant . 2009 May;15(5):537-46.

Penack O, Holler E, van den Brink MR. Graft-versus-host disease: regulation by microbe-associated molecules and innate immune receptors. Blood . 2009 Dec 30. [Epub ahead of print]

Reichle A, Hildebrandt GC. Principles of modular tumor therapy. Cancer Microenviron . 2009 Sep;2 Suppl 1:227-37. Epub 2009 Jul 11.

Saussele S, Lauseker M, Gratwohl A, Beelen DW, Bunjes D, Schwerdtfeger R, Kolb HJ, Ho AD, Falge C, Holler E, Schlimok G, Zander AR, Arnold R, Kanz L, Dengler R, Haferlach C, Schlegelberger B, Pfirrmann M, Muller MC, Schnittger S, Leitner A, Pletsch N, Hochhaus A, Hasford J, Hehlmann R. Allogeneic hematopoietic stem cell transplantation (alloSCT) for chronic myeloid leukemia in the imatinib era; evaluation of its impact within a subgroup of the randomized German CML Study IV. Blood . 2009 Nov 18. [Epub ahead of print]

Schilling E, El Chartouni C, Rehli M. Allele-specific DNA methylation in mouse strains is mainly determined by cis-acting sequences. Genome Res . 2009 Nov;19(11):2028-35. Epub 2009 Aug 17.

Schmidl C, Klug M, Boeld TJ, Andreesen R, Hoffmann P, Edinger M, Rehli M. Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity. Genome Res . 2009 Jun 3. [Epub ahead of print]

Schuster K, Gadiot J, Andreesen R, Mackensen A, Gajewski TF, Blank C. Homeostatic proliferation of naïve CD8(+) T cells depends on CD62L/L-selectin-mediated homing to peripheral LN. Eur J Immunol . 2009 Aug 5;39(11):2981-2990. [Epub ahead of print]

Sender V, Hofmeister-Mielke N, Sievert K, Teifke JP, Vogel H, Baumgart J, Pichlmeier U, Freund M, Casper J, Wolff D. Preclinical analysis of treosulfan in combination with total body irradiation as conditioning regimen prior to bone marrow transplantation in rats. Immunopharmacol Immunotoxicol . 2009;31(4):595-600.

Stevens AP, Spangler B, Wallner S, Kreutz M, Dettmer K, Oefner PJ, Bosserhoff AK. Direct and tumor microenvironment mediated influences of 5'-deoxy-5'-(methylthio)adenosine on tumor progression of malignant melanoma. J Cell Biochem . 2009 Feb 1;106(2):210-9.

Ullrich E, Bosch J, Aigner M, Völkl S, Dudziak D, Spriewald B, Schuler G, Andreesen R, Mackensen A. Advances in cellular therapy: 5th International Symposium on the clinical use of cellular products, 19 and 20 March 2009, Nürnberg, Germany. Cancer Immunol Immunother . 2009 Oct 28. [Epub ahead of print] No abstract available.

Voelkl S, Moore TV, Rehli M, Nishimura MI, Mackensen A, Fischer K. Characterization of MHC class-I restricted TCRalphabeta(+) CD4 (-) CD8 (-) double negative T cells recognizing the gp100 antigen from a melanoma patient after gp100 vaccination. Cancer Immunol Immunother . 2009 May;58(5):709-18. Epub 2008 Oct 3.

Wang XN, Haniffa MA, Holtick U, Collin MP, Jackson G, Hilkens CM, Holler E, Edinger M, Hoffmann P, Dickinson AM. Regulatory T-cell suppression of CD8+ T-cell-mediated graft-versus-host reaction requires their presence during priming. Transplantation . 2009 Jul 27;88(2):188-97.

Weigelt K, Lichtinger M, Rehli M, Langmann T. Transcriptomic profiling identifies a PU.1 regulatory network in macrophages. Biochem Biophys Res Commun . 2009 Mar 6;380(2):308-12. Epub 2009 Jan 22.

Weil T, Korb J, Rehli M. Comparison of queen-specific gene expression in related lower termite species. Mol Biol Evol . 2009 Aug;26(8):1841-50. Epub 2009 Jun 18.

Wiese CH, Bartels UE, Zausig YA, Pfirstinger J, Graf BM, Hanekop GG. Prehospital emergency treatment of palliative care patients with cardiac arrest: a retrolective investigation. Support Care Cancer. 2009 Oct 8. [Epub ahead of print]

Wolff D, Steiner B, Hildebrandt G, Edinger M, Holler E. Pharmaceutical and cellular strategies in prophylaxis and treatment of graft-versus-host disease. Curr Pharm Des . 2009;15(17):1974-97.

Yokota S, Okabayashi T, Rehli M, Fujii N, Amano K. Helicobacter pylori lipopolysaccharides upregulate toll-like receptor 4 expression and proliferation of gastric epithelial cells via the MEK1/2-ERK1/2 mitogen-activated protein kinase pathway. Infect Immun . 2010 Jan;78(1):468-76. Epub 2009 Oct 26.
 
 

Publikationen 2008

Andree H, Hilgendorf I, Leithaeuser M, Junghanss C, Holzhueter S, Loddenkemper C, Steiner B, Freund M, Wolff D. Enteral budesonide in treatment for mild and moderate gastrointestinal chronic GVHD. Bone Marrow Transplantation 2008, 42: 541-546

Baumann F, Leukel P, Doerfelt A, Beier CP, Dettmer K, Oefner PJ, Kastenberger M, Kreutz M, Nickl-Jockschat T, Bogdahn U, Bosserhoff AK, Hau P. Lactate promotes glioma migration by TGF-beta2 dependent regulation of matrix metalloproteinase-2. Neuro Oncol. 2008 Dec 5.

Bhat, KP, Pelloski CE, Zhang Y, Kim SH, deLaCruz C, Rehli M, and Aldape KD. Selective repression of YKL-40 by NF-kappaB in glioma cell lines involves recruitment of histone deacetylase-1 and -2. FEBS Lett. 2008 Sep 22; 582 (21-22), 3193-3200.

Dickinson AM, Holler E. Polymorphisms of cytokine and innate immunity genes and GVHD. Best Pract Res Clin Haematol. 2008 Jun;21(2):149-64

Edinger M, Powrie F, Chakraverty R. Regulatory mechanisms in graft-versus-host responses. Biol Blood Marrow Transplant. 2008 Jan;15(1 Suppl):2-6

Edinger M. CD4+ CD25+ regulatory T cells approach the clinic. Cytotherapy. 2008;10(7):655-6.

Gerbitz A, Hillemanns P, Schmid C, Wilke A, Jayaraman R, Kolb HJ, Eissner G, Holler E. Influence of polymorphism within the heme oxygenase-I promoter on overall survival and transplantation-related mortality after allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2008 Oct;14(10):1180-9.

Gottfried E, Kunz-Schughart LA, Weber A, Rehli M, Peuker A, Muller A, Kastenberger M, Brockhoff G, Andreesen R, and Kreutz M.  Expression of CD68 in non-myeloid cell types. Scand. J. Immunol. (2008) 67, 453-463.

Gottfried E, Kreutz M, Mackensen A. Tumor-induced Modulation of dendritic cell function. Cytokine Growth Factor Rev. (2008) 19(1):65-77 Review

Hennemann B, Ickenstein G, Sauerbruch S, Luecke K, Haas S, Horn M, Andreesen R, Bogdahn U, Winkler J. Mobilization of CD34+ hematopoietic cells, colony-forming cells and long-term culture-initiating cells into the peripheral blood of patients with an acute cerebral ischemic insult. Cytotherapy . 2008;10(3):303-11. 

Hickstein H, Wolff D, Stange J, Frei E, Hartung G. Prolonged survival of renal allograft in rats by methotrexate-albumin conjugates as immunosuppressive therapy. Transplant Proc. 2008 Dec;40(10):3725-7.

Hildebrandt GC, Granell M, Urbano-Ispizua A, Wolff D, Hertenstein B, Greinix, HT, Brenmoehl J, Schulz C, Dickinson AM, Hahn J, Rogler G, Andreesen R, Holler E. Recipient NOD2/CARD15 variants: a novel independent risk factor for the development of bronchiolitis obliterans after allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2008 Jan 14(1);67-74

Hildebrandt GC, Olkiewicz KM, Corrion LA, Clouthier SG, Liu, C Cooke KR. A role for TNF receptor type II in leukocyte infiltration into the lung during experimental idiopathic pneumonia syndrome. Biol Blood Marrow Transplant. 2008 Apr; 14 ( 4 ): 385-96

Hildebrandt, GC; Choi, SW; Mueller, G; Olkiewicz, KM; Moore, BB; Cooke, KR. The absence of donor-derived IL-13 exacerbates the severity of acute-graft-versus host disease following allogeneic bone marrow transplantation. Pediatric Blood Cancer. 2008 Apr;50(4):911-4

Hilgendorf I, Aepinus C , Wolff, D, Leithaeuser M, Junghanss C, Casper J, Freund M. Visual deterioration after gram-negative sepsis in neutropenia. Ann Hematol 2008; 87: 155-157

Hilgendorf I, Wolff D, Junghanss C, Kahl C, Leithaeuser M, Steiner B, Casper J, Freund M. Neurological complications after intrathecal liposomal cytarabine application in patients after allogeneic haematopoietic stem cell transplantation. Ann Hematol. 2008 Dec;87(12):1009-12. Epub 2008 Aug 13.

Holler E, Rogler G, Brenmoehl J, Hahn J, Greinix H, Dickinson AM, Socie G, Wolff D, Finke J, Fischer G, Jackson G, Rocha V, Hilgendorf I, Eissner G, Marienhagen J, Andreesen R. The role of genetic variants of NOD2/CARD15, a receptor of the innate immune system, in GvHD and complications following related and unrelated donor haematopoietic stem cell transplantation. Int J Immunogenet. 2008 Aug;35(4-5):381-4.

Holler E, Hahn J, Andreesen R, Rogler G, Brenmoehl J, Greinix H, Dickinson AM, Socie G, Wolff D, Finke J. NOD2/CARD15 polymorphisms in allogeneic stem-cell transplantation from unrelated donors: T depletion matters. J Clin Oncol. 2008 Jan 10;26(2):338-9; author reply 339.

Kraetzel K, Stoelcker B, Eissner G, Multhoff G, Pfeifer M, Holler E, Schulz C. NKG2D-dependent effector function of bronchial epithelium activated alloreactive T cells. Eur Respir J. 2008 Apr 16.

Marks R, Potthoff K, Hahn J, Ihorst G, Bertz H, Spyridonidis A, Holler E, Finke JM. Reduced-toxicity conditioning with fludarabine, BCNU, and melphalan in allogeneic hematopoietic cell transplantation: particular activity against advanced hematologic malignancies. Blood. 2008 Jul 15;112(2):415-25. Epub 2008 May 1.

Maier J, Birkenfeld G, Pfirstinger J, Schölmerich J, Fleck M, Brühl H. Effective treatment of steroid refractory adult-onset Still's disease with anakinra. J Rheumatol. 2008 May;35(5):939-41

Miklos S, Mueller G, Chang Y, Schubert TE, Holler E, Hildebrandt GC. Pulmonary function changes in experimental graft-versus-host disease of the lung. Biol Blood Marrow Transplant. 2008 Sep;14(9):1004-16.

Reichle A, Vogt T. Systems biologie: A therapeutic target in tumor therapy. Cancer Microenvironment 2008

Ruck S, Hilgendorf I, Müller-Hilke B, Kiefel V, Junghanss C, Freund M, Greinix H, Wolff D. Autoantibody mediated agranulocytosis in association with chronic GVHD. Bone Marrow Transplantation 2008, 42: 359-360

Schmidl C, Klug M, Boeld TJ, Hoffmann P, Edinger M, Rehli M. Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity (eingereicht).

Wolff D, Andree H, Hilgendorf I, Casper J, Freund M, Junghanss C. Sirolimus in Combination with Tacrolimus in Allogeneic Stem Cell Transplantation – Timing and Conditioning Regimen May be Crucial. Biol of Blood and Marrow Transplantation 2008, 14: 942-943
 

Publikationen 2007

Altmannsberger P, Holler E, Andreesen R, Krause SW. Amphotericin B deoxycholate: no significant advantage of a 24 h over a 6 h infusion schedule. J Antimicrob Chemother. 2007 Jul;60(1):180-2.

Baron U, Floess S, Wieczorek G, Baumann K, Grützkau A, Dong J, Thiel A, Boeld TJ, Hoffmann P, Edinger M, Türbachova I, Hamann A, Olek S, Huehn J. DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells. Eur J Immunol. 2007 Sep;37(9):2378-89.

Beier F, Balabanov S, Amberger CC, Hartmann U, Manger K, Dietz K, Kötter I, Brummendorf Th. Telomere length analysis in monocytes and lymphocytes from patients with systemic lupus erythematosus using multi-color flow-FISH. Lupus, 2007;16(12):955-62

Blank C, Mackensen A. Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion. Cancer Immunol Immunother. 2007 May;56(5):739-45. Epub 2006 Dec 29. Review.

Brenmoehl J, Holler E, Rogler G. Polymorphisms within epithelial receptors: NOD2/CARD15. Methods Mol Med. 2007;134:115-22.

Brenmoehl J, Herfarth H, Glück T, Audebert F, Barlage S, Schmitz G, Froehlich D, Schreiber S, Hampe J, Schölmerich J, Holler E, Rogler G. Genetic variants in the NOD2/CARD15 gene are associated with early mortality in sepsis patients. Intensive Care Med. 2007 Sep;33(9):1541-8. Epub 2007 Jun 9.

Brünnler T, Krause SW. Inzidenz, Ursachen und Prognose von Organversagen bei Patienten mit malignen Erkrankungen. Intensivmed. (2007) 44: 20 – 30

Brünnler T, Mandraka F, Zierhut S, Siebig S, Wrede C, Klebl F, Holler E, Salzberger B, Schoelmerich J, Langgartner J. Outcome of hemato-oncologic patients with and without stem cell transplantation in a medical ICU. Eur J Med Res. 2007 Aug 16;12(8):323-30.

Burger M, van der Aa MNM, van Oers JMM, Brinkmann A, van der Kwast Th, Steyenberg EC,Stoehr R, Kinkels WJ, Denzinger S, Wild PJ, Wieland WF, Hofstaedter F, Hartmann A, Zwarthoff EC. Prediction of progression of non-muscle-invasive bladder cancer by WHO 1863 abd 2994 grading and FGFR3 mutation status a prospective study. Eur Urol 2007, 10;19156

Choi SW*, Hildebrandt GC*, Olkiewicz KM, Hanauer DA, Chaudhary MN, Silva IA, Rogers CE, Deurloo D, Fisher JM, Liu C, Chensue SW, Cooke KR. CCR1: CCL5 (RANTES) receptor ligand interactions modulate leukocyte recruitment and allogeneic T cell responses following bone marrow transplantation. Blood. 2007 Nov 1;110(9):3447-55

Cornely OA, Maertens J, Bresnik M, Ebrahimi R, Ullmann AJ, Bouza E, Heussel CP, Lortholary O, Rieger C, Boehme A, Aoun M, Horst HA, Thiebaut A, Ruhnke M, Reichert D, Vianelli N, Krause SW, Olavarria E, Herbrecht R, on behalf of the AmBiLoad Trial Study Group. Liposomal Amphotericin B as Initial Therapy for Invasive Mould Infections: A Randomized Trial Comparing a High Loading Dose Regimen with Standard Dosing (AmBiLoad Trial). Clin. Infect. Dis. (2007) 44: 1289 – 1297

Ewing P, Hildebrandt GC, Planke S, Andreesen R, Holler E, Gerbitz A. Cobalt protoporphyrine IX-mediated heme oxygenase-I induction alters the inflammatory cytokine response, but not antigen presentation after experimental allogeneic bone marrow transplantation. Int J Mol Med. 2007 Sep;20(3):301-8.

Ewing P, Miklos S, Olkiewicz KM, Müller G, Andreesen R, Holler E, Cooke KR, Hildebrandt GC. Donor CD4+ T-cell production of tumor necrosis factor alpha significantly contributes to the early proinflammatory events of graft-versus-host disease. Exp Hematol. 2007 Jan;35(1):155-63.

Fischer K, Hoffmann P, Voelkl S, Meidenbauer N, Ammer J, Edinger M, Gottfried E, Schwarz S, Rothe G, Hoves S, Renner K, Timischl B, Mackensen A, Kunz-Schughart L, Andreesen R, Krause SW, Kreutz M. Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood. 2007 May 1;109(9):3812-9.

Garbe C, Hauschild A, Volkenandt M, Schadendorf D, Stolz W, Reinhold U, Kortmann RD, Kettelhack C, Frerich B, Keilholz U, Dummer R, Sebastian G, Tilgen W, Schuler G, Mackensen A, Kaufmann R. Evidence and interdisciplinary consense-based German guidelines: diagnosis and surveillance of melanoma. Melanoma Res. 2007 Dec;17(6):393-9.

Glas M, Hennemann B, Hirschmann B, Marienhagen J, Schmidt-Wolf I, Herrlinger U, Bogdahn U, Hau P. Complete response after treatment with a somatostatin analogue in an adult patient with resurrent medulloblastoma. Acta Oncol. 2007: 12:1-2

Gottfried E, Kreutz M, Haffner S, Holler E, Iacobelli M, Andreesen R, Eissner G. Differentiation of human tumour-associated dendritic cells into endothelial-like cells: an alternative pathway of tumour angiogenesis. Scand J Immunol. 2007 Apr;65(4):329-35.

Grassinger J, Simon M, Mueller G, Drewel D, Andreesen R, Hennemann B. Bone morphogenetic protein (BMP)-7 but not BMP-2 and BMP-4 improves maintenance of primitive peripheral blood-derived hematopoietic progenitor cells (HPC) cultured in serum-free medium supplemented with early acting cytokines. Cytokine. 2007 Dec;40(3):165-71

Grube M, Moritz S, Obermann EC, Rezvani K, Mackensen A, Andreesen R, Holler E. CD8+ T cells reactive to survivin antigen in patients with multiple myeloma. Clin Cancer Res. 2007 Feb 1;13(3):1053-60.

Hahn J, Mandraka F und Fröhlich G. Ethische Aspekte in der Therapie kritisch kranker Tumorpatienten. Intensivmedizin und Notfallmedizin 2007, Vol.44, No. 7, S: 416-428

Hart C, Blank C, Krause SW, Andreesen R, Hennemann B. Ifosfamide, epirubicin, and etoposide (IEV) mobilize peripheral blood stem cells more efficiently than cyclophosphamide/etoposide. Ann Hematol. 2007 Aug;86(8):575-81

Hau P, Kunz-Schughart L, Bogdahn U, Baumgart U, Hirschmann B, Weimann E, Muhleisen H, Ruemmele P, Steinbrecher A, Reichle A. Low-dose chemotherapy in combination with COX-2 inhibition and PPARgamma agonists in recurrent high-grade glioma-a phase II study. Oncology. 2007;73(1-2):21-5. 

Hennemann B, Dietl B. Strahlentherapie und Chemotherapie in der kuratiaven und palliativen Behandlung von Plattenepithelkarzinomen im Kopf-Hals-Bereich. TUZ Journal 2007, 1:9-16

Hildebrandt, GC. The lung´s friend, the gut´s foe. Blood, 2007 110: 792-793

Holler E. Progress in acute graft versus host disease Curr Opin Hematol. 2007 Nov;14(6):625-31. Review.

Holler E. Risk assessment in haematopoietic stem cell transplantation: GvHD prevention and treatment. Best Pract Res Clin Haematol. 2007 Jun;20(2):281-94. Review.

Kittan NA, Bergus A, Haupt S, Donhauser N, Schuster P, Korn K, Harrer T, Schmidt B. Impaired plasmacytoid dendritic cell innate immune responses in patients with herpes virusassociated acute retinal necrosis. J Immunol 2007, Sep 15 ;179(6):4219-30

Klebl F, Krause SW. Akuttherapie onkologischer Notfälle. Intensivmed. (2007) 44: 74 – 87

Koehl GE, Geissler EK, Iacobelli M, Frei C, Burger V, Haffner S, Holler E, Andreesen, Schlitt HJ, Eissner G. Defibrotide: an endothelium protecting and stabilizing drug, has an anti-angiogenic potential in vitro and in vivo. Cancer Biol Ther. 2007 May;6(5):686-90. Epub 2007 Feb 3.

Knöll A, Boehm S, Hahn J, Holler E, Jilg W. Long-term surveillance of haematopoietic stem cell recipients with resolved hepatitis B: high risk of viral reactivation even in a recipient with a vaccinated donor. J Viral Hepat. 2007 Jul;14(7):478-83.

Knop S, Hebart H, Gratwohl A, Kliem C, Faul C, Holler E, Apperley J, Kolb HJ, Schaefer A, Niederwieser D, Einsele H. Treatment of steroid-resistant acute GVHD with OKT3 and high-dose steroids results in better disease control and lower incidence of infectious complications when compared to high-dose steroids alone: a randomized multicenter trial by the EBMT Chronic Leukemia Working Party. Leukemia. 2007 Aug;21(8):1830-3

Krause SW, Holler E. Imatinib in chronic myeloid leukemia. N. Engl. J. Med. (2007) 356: 1780 (Letter)

Kröger N, Badbaran A, Holler E, Hahn J, Kobbe G, Bornhauser M, Reiter A, Zabelina T, Zander AR, Fehse B. Monitoring of the JAK2-V617F mutation by highly sensitive quantitative real-time PCR after allogeneic stem cell transplantation in patients with myelofibrosis. Blood. 2007 Feb 1;109(3):1316-21

Krüger B, Böger CA, Schröppel B, Obed A, Hoffmann U, Murphy BT, Fischereder M, Holler E, Banas B, Krämer BK. Impact of NOD2/CARD15 haplotypes on the outcome after kidney transplantation. Transpl Int. 2007 Jul;20(7):600-7.

Lichtinger M, Ingram R, Hornef M, Bonifer C, and Rehli M. Transcription factor PU.1 controls transcription start site positioning and alternative TLR4 promoter usage. J Biol Chem. 2007 Sep 14;282(37):26874-83

Pham TH, Langmann S, Schwarzfischer L, El Chartouni C, Lichtinger M, Klug M, Krause SW, Rehli M. CCAAT enhancer binding protein beta regulates constitutive gene expression during late stages of monocyte to macrophage differentiation. J Biol Chem (2007) 282: 21924 – 33

Reichle A, Vogt T, Coras B, Terheyden P, Neuber K, Trefzer U, Schultz E, Berand A, Bröcker EB, Landthaler M, Andreesen R. Targeted combined anti-inflammatory and angiostatic therapy in advanced melanoma: a randomized phase II trial. Melanoma Res. 2007 Dec;17(6):360-4.

Reichle A. Systembiologie von Tumoren: Wundheilungsmechanismen als therapeutisches Ziel. MedReview 2007, 15: 23-25.

Rothhammer T, Bataille F, Spruss T, Eissner G, Bosserhoff AK. Functional implication of BMP4 expression on angiogenesis in malignant melanoma. Oncogene. 2007 Jun 14;26(28):4158-70.

Ruutu T, Barosi G, Benjamin RJ, Clark RE, George JN, Gratwohl A, Holler E, Iacobelli M, Kentouche K, Lämmle B, Moake JL, Richardson P, Socié G, Zeigler Z, Niederwieser D, Barbui T. European Group for Blood and Marrow Transplantation; European LeukemiaNet. Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: results of a consensus process by an International Working Group. Haematologica. 2007 Jan;92(1):95-100.

Schilling E and Rehli M. Global, comparative analysis of tissue-specific promoter CpG methylation. Genomics 2007 Sep;90(3):314-23

Schmid C, Labopin M, Nagler A, Bornhäuser M, Finke J, Fassas A, Volin L, Gürman G, Maertens J, Bordigoni P, Holler E, Ehninger G, Polge E, Gorin NC, Kolb HJ, Rocha V, EBMT Acute Leukemia Working Party. Donor lymphocyte infusion in the treatment of first hematological relapse after allogeneic stem-cell transplantation in adults with acute myeloid leukemia: a retrospective risk factors analysis and comparison with other strategies by the EBMT Acute Leukemia Working Party. J Clin Oncol. 2007 Nov 1;25(31):4938-45

Schmidt-Hieber M, Blau IW, Trenschel R, Andreesen R, Stuhler G, Einsele H, Kanz L, Keilholz U, Marinets O, Beelen DW, Fauser AA, Volin L, Ruutu T, Uharek L, Fietz T, Knauf W, Hopfenmüller W, Thiel E, Freund M, Casper J. Reduced-toxicity conditioning with fludarabine and treosulfan prior to allogeneic stem cell transplantation in multiple myeloma. Bone Marrow Transplant. 2007 Apr;39(7):389-96. Epub 2007 Feb 19.

Schroder K, Lichtinger M, Irvine KM, Brion K, Trieu A, Ross IL, Ravasi T, Stacey KJ, Rehli M, Hume DA, and Sweet MJ. PU.1 and ICSBP control constitutive and IFN-{gamma}-regulated Tlr9 gene expression in mouse macrophages. J Leukoc Biol 2007 Jun; 81 (6), 1577-90.

Vogelhuber M, Wagner H, Gesinn S, Schön I, Andreesen R. Einrichtung eines Psychoonkologischen Dienstes in der Abteilung Hämatologie und Internistische Onkologie der Uniklinik Regensburg. Deutsche Zeitschrift für Onkologie 2007; 39: 28-32

Weigelt K, Ernst W, Walczak Y, Ebert S, Loenhardt T, Klug M, Rehli M, Weber BH, Langmann T. Dap12 expression in activated microglia from retinoschisin-deficient retina and its PU.1-dependent promoter regulation. J Leukoc Biol. 2007 Dec;82(6):1564-74

Weil T, Rehli M*, and Korb J. Molecular basis for the reproductive division of labour in a lower termite. BMC Genomics 2007 Jun 28;8, 198.

Weissinger EM, Schiffer E, Hertenstein B, Ferrara JL, Holler E, Stadler M, Kolb HJ, Zander A, Zürbig P, Kellmann M, Ganser A. Proteomic patterns predict acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Blood. 2007 Jun 15;109(12):5511-9
 

Publikationen 2006

Blank C, Mackensen A. Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion. Cancer Immunol Immunother; Epub 2006 Dec 29

Blank C, Kuball J, Voelkl S, Wiendl H, Becker B, Walter B, Majdic O, Gajewski TF,Theobald M, Andreesen R, Mackensen A. Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro. Int J Cancer. 2006 Jul 15;119(2):317-27

Bock J, Doenitz A, Andreesen R, Reichle A, Hennemann B. Pericarditis after high-dose chemotherapy: more frequent than expected? Onkologie. 2006 Jul;29(7):321-4.

Bouazzaoui A, Kreutz M, Eisert V, Dinauer N, Heinzelmann A, Hallenberger S, Strayle J, Walker R, Rubsamen-Waigmann H, Andreesen R, von Briesen H. Stimulated trans-acting factor of 50 kDa (Staf50) inhibits HIV-1 replication in human monocyte-derived macrophages. Virology. 2006 Dec 5-20;356(1-2):79-94.

Buchner T, Berdel WE, Schoch C, Haferlach T, Serve HL, Kienast J, Schnittger S, Kern W, Tchinda J, Reichle A, Lengfelder E, Staib P, Ludwig WD, Aul C, Eimermacher H, Balleisen L, Sauerland MC, Heinecke A, Wormann B, Hiddemann W. Double induction containing either two courses or one course of high-dose cytarabine plus mitoxantrone and postremission therapy by either autologous stem-cell transplantation or by prolonged maintenance for acute myeloid leukemia. J Clin Oncol. 2006 Jun 1;24(16):2480-9.

Cooke, KR, Hildebrandt G: Pulmonary toxicity following hematopoietic cell transplantation: Is the lung a target organ of graft-versus-host disease ? Current Opinion in Organ Transplantation 2006; 11(1):69-77

Drewel D, Luecke K, Mueller G, Kunz-Schughart LA, Dietl B, Zeitler I, Andreesen R, Hennemann B. SCF modulates organ distribution and hematopoietic engraftment of CB-derived pluripotent HPC transplanted in NOD/SCID mice. Cytotherapy. 2006;8(1):70-8.

Fischer K, Voelkl S, Berger J, Andreesen R, Pomorski T, Mackensen A. Antigen recognition induces phosphatidylserine exposure on the cell surface of human CD8+ T cells. Blood. 2006 Dec 15;108(13):4094-101.

Fischer K, Hoffmann P, Voelkl S, Meidenbauer N, Ammer J, Edinger M, Gottfried E, Schwarz S, Rothe G, Hoves S, Renner K, Timischl B, Mackensen A, Kunz-Schughart L, Andreesen R, Krause SW & M Kreutz M. Inhibitory effect of tumor cell derived lactic acid on human T cells. Blood Epub 2006 Dec.

Fraunberger P, Wang Y, Holler E, Parhofer KG, Nagel D, Walli AK, Seidel D. Prognostic value of interleukin 6, procalcitonin, and C-reactive protein levels in intensive care unit patients during first increase of fever. Shock. 2006 Jul;26(1):10-2.

Garbe C, Hauschild A, Volkenandt M, Schadendorf D, Stolz W, Kortmann RD, Kettelhack C, Frerich B, Keilholz U, Dummer R, Sebastian G, Tilgen W, Schuler G, Mackensen A, Kaufmann R. [Brief guidelines: malignant melanoma of the skin]. J Dtsch Dermatol Ges. 2006 Apr;4(4):344-9.

Gebhard C, Schwarzfischer L, Pham TH, Andreesen R, Mackensen A, Rehli M. Rapid and sensitive detection of CpG-methylation using methyl-binding (MB)-PCR. Nucleic Acids Res. 2006 Jul 5; 34(11): e82. PMID: 16822855

Gebhard C, Schwarzfischer l, Pham TH, Schilling E, Klug M, Andreesen R, Rehli M. Genome-wide profiling of CpG methylation identifies novel targets of aberrant hypermethylation in myeloid leukemia. Cancer Res. 2006 Jun 15;66(12):6118-28.

Glasmacher A, Cornely O, Ullmann AJ, Wedding U, Bodenstein H, Wandt H, Boewer C, Pasold R, Wolf HH, Hanel M, Dolken G, Junghanss C, Andreesen R, Bertz H; Itraconazole Research Group of Germany. An open-label randomized trial comparing itraconazole oral solution with fluconazole oral solution for primary prophylaxis of fungal infections in patients with haematological malignancy and profound neutropenia. J Antimicrob Chemother. 2006 Feb;57(2):317-25.

Gottfried E, Rehli M, Hahn J, Holler E, Andreesen R, Kreutz M. Monocyte-derived cells express CYP27A1 and convert vitamin D3 into its active metabolite. Biochem Biophys Res Commun. 2006 Oct 13;349(1):209-13.

Gottfried E, Kunz-Schughart LA, Andreesen R, Kreutz M. Brave little world: spheroids as an in vitro model to study tumor-immune-cell interactions. Cell Cycle. 2006 Apr;5(7):691-5.

Gottfried E, Kunz-Schughart LA, Ebner S, Mueller-Klieser W, Hoves S, Andreesen R, Mackensen A, Kreutz M. Tumor-derived lactic acid modulates dendritic cell activation and antigen expression. Blood. 2006 Mar 1;107(5):2013-21.

Grassinger J, Mueller G, Zaiss M, Kunz-Schughart LA, Andreesen R, Hennemann B. Differentiation of hematopoietic progenitor cells towards the myeloid and B-lymphoid lineage by hepatocyte growth factor (HGF) and thrombopoietin (TPO) together with early acting cytokines. Eur J Haematol. 2006 Aug;77(2):134-44

Grassinger J, Sudhoff T, Andreesen R, Hennemann B. Complete remission and successful stem cell mobilization after treatment of refractory plasma cell leukemia with bortezomib. Ann Hematol. 2006 Feb;85(2):132-3.

Greinix HT, Socie G, Bacigalupo A, Holler E, Edinger MG, Apperley JF, Schwarz T, Ullrich SE, Albert ML, Knobler RM, Peritt D, Ferrara JL. Assessing the potential role of photopheresis in hematopoietic stem cell transplant. Bone Marrow Transplant. 2006 Aug;38(4):265-73.

Hennemann B. Palliative Chemotherapie von Kopf-Hals-Tumoren: Aktueller Stand und neue Entwicklungen. Laryngo-Rhino-Otolog 2006; 85: 172-178

Hoffmann P, Eder R, Boeld TJ, Doser K, Piseshka B, Andreesen R, Edinger M. Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood. 2006 Dec 15;108(13):4260-7.

Hoffmann P, Boeld TJ, Eder R, Albrecht J, Doser K, Piseshka B, Dada A, Niemand C, Assenmacher M, Orso E, Andreesen R, Holler E, Edinger M. Isolation of CD4+CD25+ regulatory T cells for clinical trials. Biol Blood Marrow Transplant. 2006 Mar;12(3):267-74

Hofffmann P. & M Edinger. CD4 + CD25 + regulatory T cells and graft-versus-host disease. Semin Hematol. 2006, 43(1): 62-69.

Holler E, Rogler G, Brenmoehl J, Hahn J, Herfarth H, Greinix H, Dickinson AM, Socie G, Wolff D, Fischer G, Jackson G, Rocha V, Steiner B, Eissner G, Marienhagen J, Schoelmerich J, Andreesen R. Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination. Blood. 2006 May 15;107(10):4189-93.

Hoves S, Krause SW, Schutz C, Halbritter D, Scholmerich J, Herfarth H, Fleck M. Monocyte derived human macrophages mediate anergy in allogeneic T cells and induce regulatory T cells. J. Immunol. 2006, 177: 2691 – 2698

Kroger N, Badbaran A, Holler E, Hahn J, Kobbe G, Bornhauser M, Reiter A, Zabelina T, Zander AR, Fehse B. Monitoring of V617F-JAK2-mutation by highly sensitive quantitative real-time PCR after allogeneic stem cell transplantation in patients with myelofibrosis. Blood. Epub 2006 Oct 3;

Lanning EM, Holtick U, Dickinson AM, Holler E, Gluckman E, Hromadnikova I, Middleton PG, Collin MP. Impact of mismatching CD1a, a dimorphic antigen-presenting molecule, on graft-versus-host disease after hematopoietic stem cell transplantation. Transplantation 2006 Nov 27;82(10):1374-6.

Lefebvre ML, Krause SW, Salcedo M, Nardin A Ex vivo-activated human macrophages kill chronic lymphoid leukemia cells in the presence of rituximab: mechanism of ADCC and impact of human serum. J Immunother., 2006, 29: 388 – 397

Mackensen A, Meidenbauer N, Vogl S, Laumer M, Berger J, Andreesen R. Phase I study of adoptive T-cell therapy using antigen-specific CD8+ T cells for the treatment of patients with metastatic melanoma. J Clin Oncol. 2006 Nov 1;24(31):5060-9.

Multhoff G, DeMaio A. Stress down south: meeting report of the fifth International Workshop on the Molecular Biology of Stress Responses. Cell Stress & Chaperones 11: 2006

Nguyen TT, Gehrmann M, Zlacka D, Sosna A, Vavarincova P, Multhoff G, Hromadnikova I. Hsp70 membrane expression on fibroblast-like synovial cells derived from synovial tissue of patients with rheumatoid and juvenile arthritis. Scand J Rheumatol. 2006 Nov-Dec;35(6):447-53

Pihusch M, Pihusch R, Fraunberger P, Pihusch V, Andreesen R, Kolb HJ, Holler E. Evaluation of C-reactive protein, interleukin-6, and procalcitonin levels in allogeneic hematopoietic stem cell recipients. Eur J Haematol. 2006 Feb;76(2):93-101

Radons J, Stangl S, Multhoff G: NK cell based immunotherapies against solid tumors. Central European Journal of Medicine 1 (3): 179-204, 2006

Rothhammer T, Bataille F, Spruss T, Eissner G, Bosserhoff AK. Functional implication of BMP4 expression on angiogenesis in malignant melanoma. Oncogene. 2006 Dec 18; [Epub ahead of print]

Schmid FX, Vudattu N, Floerchinger B, Hilker M, Eissner G, Hoenicka M, Schultz KR, Miklos DB, Fowler D, Cooke K, Shizuru J, Zorn E, Holler E, Ferrara J, Shulman H, Lee SJ, Martin P, Filipovich AH, Flowers ME, Weisdorf D, Couriel D, Lachenbruch PA, Mittleman B, Vogelsang GB, Pavletic SZ. Toward biomarkers for chronic graft-versus-host disease: National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: III. Biomarker Working Group Report. Biol Blood Marrow Transplant. 2006 Feb;12(2):126-37.

Schmid FX, Floerchinger B, Vudattu NK, Eissner G, Haubitz M, Holler E, Andreesen R, Birnbaum DE. Direct evidence of endothelial injury during cardiopulmonary bypass by demonstration of circulating endothelial cells. Perfusion. 2006 May;21(3):133-7

Stangl S, Wortmann A, Gürtler U, Multhoff G: Control of metastasized pancreatic carcinomas in SCID/beige mice with human TKDactivated NK cells. J Immunol 176: 6270-6276, 2006 (7.0)

Steiner K, Graf M, Hecht K, Reif S, Rossbacher L, Pfister K, Kolb HJ, Schmetzer H, Multhoff G: High Hsp70 membrane expression on leukemic cells from patients with acute myeloid leukemia is associated with worse prognosis. Leukemia ,1-3, 2006

Shafqat N, Shafqat J, Eissner G, Marschall HU, Tryggvason K, Eriksson U, Gabrielli F, Lardy H, Jornvall H, Oppermann U. Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH dependent dicarbonyl reductase expressed in vascular endothelial tissue. Cell Mol Life Sci. 2006 May;63(10):1205-13.

Vogt T, Coras B, Hafner C, Landthaler M, Reichle A. Antiangiogenic therapy in metastatic prostate carcinoma complicated by cutaneous lupus erythematodes. Lancet Oncol. 2006 Aug;7(8):695-7.

Walton SM, Gerlinger M, de la Rosa O, Nuber N, Knights A, Gati A, Laumer M, Strauss L, Exner C, Schafer N, Urosevic M, Dummer R, Tiercy JM, Mackensen A, Jaeger E, Levy F, Knuth A, Jager D, Zippelius A. Spontaneous CD8 T cell responses against the melanocyte differentiation antigen RAB38/NY-MEL-1 in melanoma patients. J Immunol. 2006 Dec 1;177(11):8212-8.

Wassmann B, Pfeifer H, Goekbuget N, Beelen DW, Beck J, Stelljes M, Bornhauser M, Reichle A, Perz J, Haas R, Ganser A, Schmid M, Kanz L, Lenz G, Kaufmann M, Binckebanck A, Bruck P, Reutzel R, Gschaidmeier H, Schwartz S, Hoelzer D, Ottmann OG. Alternating versus concurrent schedules of imatinib and chemotherapy as front-line therapy for Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). Blood. 2006 Sep 1;108(5):1469-77.

Wang XN, Collin M, Sviland L, Marshall S, Jackson G, Schulz U, Holler E, Karrer S, Greinix H, Elahi F, Hromadnikova I, Dickinson AM. Skin explant model of human graft-versus-host disease: prediction of clinical outcome and correlation with biological risk factors. Biol Blood Marrow Transplant. 2006 Feb;12(2):152-9.

Wolff D, Wilhelm S, Hahn J, Gentilini C, Hilgendorf I, Steiner B, Kahl C, Junghanss C, Hartung G, Casper J, Uharek L, Holler E, Freund M. Replacement of calcineurin inhibitors with daclizumab in patients with transplantation associated microangiopathy or renal insufficiency associated with graft-versus-host disease. Bone Marrow Transplant. 2006 Sep;38(6):445-51.
 

Publikationen 2005

Bausero MA, Gastpar R, Multhoff G, Asea A. Alternative mechanism by which IFN-gamma enhances tumor recognition: active release of heat shock protein 72.J Immunol. 2005 Sep 1;175(5):2900-12

Beelen DW, Trenschel R, Casper J, Freund M, Hilger RA, Scheulen ME, Basara N, Fauser AA, Hertenstein B, Mylius HA, Baumgart J, Pichlmeier U, Hahn JR, Holler E.Dose-escalated treosulphan in combination with cyclophosphamide as a new preparative regimen for allogeneic haematopoietic stem cell transplantation in patients with an increased risk for regimen-related complications.Bone Marrow Transplant. 2005 Feb;35(3):233-41

Buechner T, Berdel WE, Schoch C, Haferlach T, Serve HL, Schnittger S, Kern W, Tchinda J, Reichle A, Staib P, Ludwig WD, Aul C, Sauerland MC, Heinecke A, Woermann B, Hiddemann W; German Acute Myeloid Leukemia Cooperative Group (AMLCG). Treatment of AML in biological subgroups. Hematology. 2005;10 Suppl 1:281-85

Buchner T, Berdel WE, Wormann B, Schoch C, Haferlach T, Schnittger S, Kern W, Aul C, Lengfelder E, Schumacher A, Reichle A, Staib P, Balleisen L, Eimermacher H, Gruneisen A, Rasche H, Sauerland MC, Heinecke A, Mesters RM, Serve HL, Kienast J, Hiddemann W. Treatment of older patients with AML. Crit Rev Oncol Hematol. 2005 Nov;56(2):247-59. Review

Blank C, Gajewski TF and Mackensen A. Interaction of PD-L1 on Tumor cells with PD-1 on Tumor-specific T cells as a Mechanism of Immune Evasion – Implications for Tumor Immunotherapy. Cancer Immunol Immunother. 54 (2005) 307-14

Blank C, Markiewicz MA, Brown , and Gajewski TF. ICAM-1 contributes to but is not absolutely required for CD8+ T cell-mediated tumor rejection in vivo. J Immunol. 174 (2005) 3416-20

Blank C and Mackensen A. Wie Tumorzellen dem Immunsystem entkommen – PD-1/PD-L1 Interaktion als neuer Mechanismus bei der Tumorresistenz. Journal Onkologie 5 (2005) 36-38

Duda E, Nagy T, Mannel DN, Eißner G: Signaling and Reverse Signaling in the Tumor Necrosis Factor/TNF Receptor System, in Damjanovich S (ed.): Biophysical aspects of receptor signaling, Berlin, Heidelberg, New York 2005, Springer, pp 171-209

Ehrnsperger A, Rehli M, Thu-Hang P, Kreutz M. Epigenetic regulation of the dendritic cell-marker gene ADAM19.Biochem Biophys Res Commun. 2005 Jul 1;332(2):456-64

Eissner G, Iacobelli M, Bluml S, Burger V, Haffner S, Andreesen R, Holler E.Oligotide, a defibrotide derivative, protects human microvascular endothelial cells against fludarabine-induced activation, damage and allogenicity.Bone Marrow Transplant. 2005 May;35(9):915-20

Ermann, J., Hoffmann, P., Edinger, M., Dutt, S., Higgins, J., Negrin, R.S., Fathman, C.G., Strober, S. (2005). Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD. Blood, 105: 2220-2226

Ewing P, Wilke A, Eissner G, Holler E, Andreesen R, Gerbitz A. Expression of heme oxygenase-1 protects endothelial cells from irradiation-induced apoptosis. Endothelium. 2005 May-Jun;12(3):113-9

Fischer K., S. Voelkl, J. Heymann, G.K. Przybylski, K. Mondal, M. Laumer, L. Kunz-Schughart, C.A. Schmidt, R. Andreesen, and A. Mackensen. Isolation and characterization of human antigen-specific TCRab+ CD4-CD8- double negative regulatory T cells. Blood. 105: 2828-2835, 2005.

Fujiwara H, Melenhorst JJ, El Ouriaghli F, Kajigaya S, Grube M, Sconocchia G, Rezvani K, Price DA, Hensel NF, Douek DC, Barrett AJ. In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins. Clin Cancer Res. 2005 Jun 15;11(12):4495-503

Furtner M, Straub RH, Kruger S, Schwarz H. Levels of soluble CD137 are enhanced in sera of leukemia and lymphoma patients and are strongly associated with chronic lymphocytic leukemia. Leukemia. 2005 May;19(5):883-5

Gastpar R, Gehrmann M, Bausero M, Asea A, Gross C, Schroeder J, Multhoff G: Hsp70 surface-positive tumor-exosomes stimulate migratory and cytolytic activity of NK cells. Cancer Res 65(12): 5238-47, 2005

Gehrmann M, Marienhagen J, Eichholtz-Wirth H, Fritz E, Ellwart J, Jäättelä M, Zilch T, Multhoff G: Dual function of membrane-bound Hsp70, Bag-4 and Hsp40: protection against radiation-induced effects and target structure for NK cells. Cell Death and Differentiation 12: 38-51, 2005

Gehrmann M, Schönberger J, Zilch T, Rossbacher L, Thonigs G, Eilles C, Multhoff G: Retinoid- and sodium-butyrate induced decrease in heat shock protein 70 membrane-positive tumor cells is associated with reduced sensitivity to NK cell lysis, growth delay, and altered growth morphology. Cell Stress & Chaperones 10(2): 136-146, 2005

Gerbitz A, Ewing P, Olkiewicz K, Willmarth NE, Williams D, Hildebrandt G, Wilke A, Liu C, Eissner G, Andreesen R, Holler E, Guo R, Ward PA, Cooke KR. A role for CD54 (intercellular adhesion molecule-1) in leukocyte recruitment to the lung during the development of experimental idiopathic pneumonia syndrome. Transplantation. 2005 Mar 15;79(5):536-42

Glasmacher A, Cornely O, Ullmann AJ, Wedding U, Bodenstein H, Wandt H, Boewer C, Pasold R, Wolf HH, Hanel M, Dolken G, Junghanss C, Andreesen R, Bertz H. An open-label randomized trial comparing itraconazole oral solution with fluconazole oral solution for primary prophylaxis of fungal infections in patients with haematological malignancy and profound neutropenia.J Antimicrob Chemother. 2006 Feb;57(2):317-25.

Gottfried E, Kunz-Schughart LA, Ebner S, Mueller-Klieser W, Hoves S, Andreesen R, Mackensen A, Kreutz M. Tumor-derived lactic acid modulates dendritic cell activation and antigen expression.Blood. 2005 Nov 8

Hafner C, Reichle A, Vogt T. New indications for established drugs: combined tumor-stroma-targeted cancer therapy with PPARgamma agonists, COX-2 inhibitors, mTOR antagonists and metronomic chemotherapy.Curr Cancer Drug Targets. 2005 Sep;5(6):393-419. Review

Hildebrandt GC, Olkiewicz KM, Choi S, Corrion LA, Clouthier SG, Liu C, Serody JS, Cooke KR. Donor T-cell production of RANTES significantly contributes to the development of idiopathic pneumonia syndrome after allogeneic stem cell transplantation. Blood. 2005 Mar 15;105(6):2249-57

Hoffmann, P., Boeld, T.J., Piseshka, B, Edinger, M. Immunomodulation after allogeneic bone marrow transplantation by CD4+CD25+ regulatory T cells. Microbes Infect. 2005 Jun;7(7-8):1066-72. Review

Hoffmann, P, Ermann, J., Edinger, M. CD4+CD25+ regulatory T cells in allogeneic stem cell transplantation. Curr Top Microbiol Immunol. 2005;293:265-85. Review

Knop S, Hebart H, Gscheidle H, Holler E, Kolb HJ, Niederwieser D, Einsele H. OKT3 muromonab as second-line and subsequent treatment in recipients of stem cell allografts with steroid-resistant acute graft-versus-host disease. Bone Marrow Transplant. 2005 Nov;36(9):831-7

Konur A, Schulz U, Eissner G, Andreesen R, Holler E. Interferon (IFN)-gamma is a main mediator of keratinocyte (HaCaT) apoptosis and contributes to autocrine IFN-gamma and tumour necrosis factor-alpha production. Br J Dermatol. 2005 Jun;152(6):1134-42

Kranzer K, Sollner L, Aigner M, Lehn N, Deml L, Rehli M, Schneider-Brachert W. in PMC Impact of Helicobacter pylori virulence factors and compounds on activation and maturation of human dendritic cells.Infect Immun. 2005 Jul;73(7):4180-9

Leemhuis, T., Wells, S., Scheffold, C., Edinger, M., Negrin, R. A phase I trial of autologous cytokine-induced killer cells for the treatment of relapsed Hodgkins disease and non-Hodgkin lymphoma Biol. Blood Marrow Transplant. 2005 Mar;11(3):181-7.

Kuchenbauer F, Schoch C, Holler E, Haferlach T, Hiddemann W, Schnittger S. A rare case of acute myeloid leukemia with a CHIC2-ETV6 fusiongen and multiple other molecular aberrations. Leukemia. 2005 Dec;19(12):2366-8

Mack M, Pfirstinger J, Haas J, Nelson PJ, Kufer P, Riethmuller G, Schlondorff D. Preferential targeting of CD4-CCR5 complexes with bifunctional inhibitors: a novel approach to block HIV-1 infection. J Immunol. 2005 Dec 1;175(11):7586-93

Meidenbauer N. and A. Mackensen. Tracking adoptively transferred antigen-specific T cell with peptide-MHC multimers. Methods Mol. Med., 109:185-200, 2005.

Pihusch M, Boeck S, Hamann M, Pihusch V, Heller T, Diem H, Rolf B, Pihusch R, Andreesen R, Holler E, Kolb HJ. Peripheral dendritic cell chimerism in allogeneic hematopoietic stem cell recipients. Transplantation. 2005 Sep 27;80(6):843-9

Pihusch M, Wegner H, Goehring P, Salat C, Pihusch V, Andreesen R, Kolb HJ, Holler E, Pihusch R. C and procollagen III peptide levels in patients with hepatic dysfunction after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2005 Oct;36(7):631-7

Pihusch M, Wegner H, Goehring P, Salat C, Pihusch V, Hiller E, Andreesen R, Kolb HJ, Holler E, Pihusch R. Diagnosis of hepatic veno-occlusive disease by plasminogen activator inhibitor-1 plasma antigen levels: a prospective analysis in 350 allogeneic hematopoietic stem cell recipients.Transplantation. 2005 Nov 27;80(10):1376-82

Plentz A, Hahn J, Knoll A, Holler E, Jilg W, Modrow S. Exposure of hematologic patients to parvovirus B19 as a contaminant of blood cell preparations and blood products. Transfusion. 2005 Nov;45(11):1811-5

Radons J, Multhoff G: Immunostimulatory functions of membrane-bound and exported Hsp70. Exercise in Immunology Reviews 11:17-33, 2005

Radons, J., Groß, C., Stangl, S. & Multhoff, G. (2005). Nucleofection of non-B cells with mini-Epstein Barr virus DNA. J. Immunol. Method. 303, 135 - 141

Rehli M, Sulzbacher S, Pape S, Ravasi T, Wells CA, Heinz S, Sollner L, El Chartouni C, Krause SW, Steingrimsson E, Hume DA, Andreesen R. Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor. J Immunol. 2005 Jun 1;174(11):7111-22

Reichle A, Vogt T, Kunz-Schughart L, Bretschneider T, Bachthaler M, Bross K, Freund S, Andreesen R.Anti-inflammatory and angiostatic therapy in chemorefractory multisystem Langerhans' cell histiocytosis of adults.Br J Haematol. 2005 Mar;128(5):730-2

Ruutu T, Corradini P, Gratwohl A, Holler E, Apperley J, Dini G, Rocha V, Schmitz N, Socie G, Niederwieser D. Use of intrathecal prophylaxis in allogeneic haematopoietic stem cell transplantation for malignant blood diseases: a survey of the European Group for Blood and Marrow Transplantation (EBMT).Bone Marrow Transplant. 2005 Jan;35(2):121-4

Rusev G, Schwengner R, Donau F, Frauendorf S, Kaubler L, Kostov LK, Mallion S, Schilling KD, Wagner A, Grosse E, von Garrel H, Kneissl U, Kohstall C, Kreutz M, Pitz HH, Scheck M, Stedile F, von Brentano P, Jolie J, Linnemann A, Pietralla N, Werner V. Decay of 1+ states as a new probe of the structure of 0+ shape isomers.Phys Rev Lett. 2005 Aug 5;95(6):062501.

Scheibl K, Schreyer AG, Kullmann F, Reichle A, Bolder U, Scholmerich J, Feuerbach S, Herfarth H, Seitz J.Magnetic resonance imaging gastrography: evaluation of the dark lumen technique compared with conventional gastroscopy in patients with malignant gastric disease.Invest Radiol. 2005 Mar;40(3):164-72

Sconocchia G, Keyvanfar K, El Ouriaghli F, Grube M, Rezvani K, Fujiwara H, McCoy JP Jr, Hensel N, Barrett AJ. Phenotype and function of a CD56+ peripheral blood monocyte. Leukemia. 2005 Jan;19(1):69-76.
von Bubnoff N, Sandherr M, Schlimok G, Andreesen R, Peschel C, Duyster J. Myeloid blast crisis evolving during imatinib treatment of an FIP1L1-PDGFR alpha-positive chronic myeloproliferative disease with prominent eosinophilia. Leukemia. 2005 Feb;19(2):286-7

Verneris, M.R., Arshi, A., Edinger, M., Kornacker, M., Natkunam, Y., Karami, M., Cao, Y., Marina, N., Contag, C and R. Negrin (2005). Ewing’s family tumor cell lines express low levels of Her2/neu which can be used as a target to redirect ex vivo activated and expanded T cells. Clin Cancer Res. 11(12):4561-70

Vudattu NK, Holler E, Ewing P, Schulz U, Haffner S, Burger V, Kirchner S, Andreesen R, Eißner G: Reverse signaling of membrane integrated tumor necrosis factor (mTNF) differentially regulates alloresponses of CD4+ and CD8+ T cells against human microvascular endothelial cells. Immunology 2005 Aug;115:536-543

Wiest R, Klouche M, Harle P, Bross K, Blaszyk H, Fischereder M, Reng CM. Acquired combined factor X and XII deficiency with isolated bleeding complications in a patient with AL amyloidosis. Ann Hematol. 2005 Mar;84(3):196-9

Wolff D, Roessler V, Steiner B, Wilhelm S, Weirich V, Brenmoehl J, Leithaeuser M, Hofmeister N, Junghanss C, Casper J, Hartung G, Holler E, Freund M.Treatment of steroid-resistant acute graft-versus-host disease with daclizumab and etanercept. 2005 May;35(10):1003-10
 

Publikationen 2004

Becker B, Multhoff G, Farkas B, P-J. Wild, Landthaler M, Stolz W, Vogt T: Induction of Hsp90 protein expression in malignant melanomas and melanoma metastases. Exp Dermatol, 13: 27-32, 2004

Blank C, Brown I, Peterson AC, Spiotto M, Iwai Y, Honjo T, Gajewski TF. PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells. Cancer Res. 2004 Feb 1;64(3):1140-5. PMID: 14871849

Eißner G, Kolch W, Scheurich P: Ligands working as receptors: Reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system. Cytokine Growth Factor Rev, im Druck [IF 9,7]

Ganster A, Brucker I, Holler E, Hahn J, Bremm H, Andreesen R, Eißner G: In vitro monitoring of endothelial complications following hematopoetic allogeneic stem cell transplantation. Bone Marrow Transplant, Bone Marrow Transplant 33:355-357, 2004 [IF 2,6]

Gastpar R, Gross C, Rossbacher L, Ellwart J, Riegger J, Multhoff G: Soluble Hsp70-peptide induces both, migration and cytolytic activity in CD3-CD94+CD56+ NK cells. JI 172: 972-980, 2004

Gehrmann M, Gross C, Dickinson A, Kolb HJ, Hiddemann W, Multhoff G: Hsp70 membrane expression, a leukaemia-specific marker in different haematological malignanacies. Immunology 88: 505-509, 2004.

Gehrmann M, Brunner M, Pfister K, Reichle A, Kremmer E, Multhoff G: Differential up-regulation of cytosolic and membrane-bound heat shock protein 70 (Hsp70) in tumor cells by anti-inflammatory drugs. Clinical Cancer Research 10: 3354-3364, 2004

Gerbitz A, Schultz M, Wilke A, Linde HJ, Schoelmerich J, Andreesen R, Holler E. Probiotic Effects on Experimental Graft-Versus-Host-Disease: Let Them Eat Yoghurt. Blood. 2004 Feb 12 [IF 9,3]

Gerbitz A, Ewing P, Wilke A, Schubert T, Eissner G, Dietl B, Andreesen R, Cooke KR, Holler E.
Induction of heme oxygenase-1 before conditioning results in improved survival and reduced graft-versus-host disease after experimental allogeneic bone marrow transplantation. Biol Blood Marrow Transplant. 2004 Jul;10(7):461-72.

Gerbitz A, Nickoloff BJ, Olkiewitz K, Willmarth NE, Hildebrandt G, Liu C, Kobzik L, Eißner G, Holler E, Ferrara JLM, Cooke KR: A role for TNFa mediated endothelial apoptosis in the development of experimental idiopathic pneumonia syndrome. Transplantation, im Druck [IF 4,2]

Hart C, Drewel D, Mueller G, Grassinger J, Zaiss M, Kunz-Schughart LA, Andreesen R, Reichle A, Holler E, Hennemann B. Expression and function of homing-essential molecules and enhanced in vivo homing ability of human peripheral blood-derived hematopoietic progenitor cells after stimulation with stem cell factor. Stem Cells. 2004;22(4):580-9

Haenssle HA, Krause SW, Emmert S, Zutt M, Kretschmer L, Schmidberger H, Andreesen R, Soruri A. Hybrid cell vaccination in metastatic melanoma: clinical and immunologic results of a phase I/II study. J Immunother. 2004 Mar-Apr;27(2):147-55.

Hoffmann P, Eder R, Kunz-Schughart LA, Andreesen R, Edinger M. Large-scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells. Blood. 2004 Aug 1;104(3):895-903. Epub 2004 Apr 15.

Holler E, Rogler G, Herfarth H, Brenmoehl J, Wild PJ, Hahn J, Eissner G, Scholmerich J, Andreesen R. Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation. Blood. 2004 Aug 1;104(3):889-94. Epub 2004 Apr 15.

Hoves S, Krause SW, Herfarth H, Halbritter D, Zhang HG, Mountz JD, Scholmerich J, Fleck M. Elimination of activated but not resting primary human CD4+ and CD8+ T cells by Fas ligand (FasL/CD95L)-expressing Killer-dendritic cells. Immunobiology. 2004;208(5):463-75.

Kaiser T, Kamal H, Rank A, Kolb HJ, Holler E, Ganser A, Hertenstein B, Mischak H, Weissinger EM. Proteomics applied to the clinical follow up of patients after allogeneic hematopoietic stem cell transplantation. Blood. 2004 Mar 30 [Epub ahead of print] [IF 9,3]

Kirchner S, Boldt S, Kolch W, Haffner S, Kazak S, Janosch P, Holler E, Andreesen R, Eissner G. LPS resistance in monocytic cells caused by reverse signaling through transmembrane TNF (mTNF) is mediated by the MAPK/ERK pathway. J Leukoc Biol. 2004 Feb;75(2):324-31. Epub 2003 Nov 11. [IF 4,5]

Knoll A, Boehm S, Hahn J, Holler E, Jilg W. Reactivation of resolved hepatitis B virus infection after allogeneic haematopoietic stem cell transplantation. Bone Marrow Transplant. 2004 Mar 8 [Epub ahead of print] [IF 2,6]

Krause SW, Gastpar R, Andreesen R, Gross C, Ullrich H, Thonigs G, Pfister K, Multhoff G.
Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: a clinical phase i trial. Clin Cancer Res. 2004 Jun 1;10(11):3699-707.

Kreutz M, Eissner G, Hahn J, Andreesen R, Drobnik W, Holler E. Variations in 1 alpha,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 serum levels during allogeneic bone marrow transplantation. Bone Marrow Transplant. 2004 Apr;33(8):871-3.

Kreutz M, Eißner G, Andreesen R, Drobnik W, Holler E: Variations in 1a,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 levels during allogeneic bone marrow transplantation. Bone Marrow Transplant 33:871-873, 2004 [IF 2,6]

Mandl, S.J., C. Mari, M. Edinger, R.S. Negrin, J.F. Tait, C.H. Contag, and F.G. Blankenberg. 2004. Multi-modality imaging identifies key times for annexin V imaging as an early predictor of therapeutic outcome. Mol Imaging 3.1-8. [IF 3,169]

 
Multhoff G, Pfister K, Hromadnikova I, Zlacka D. Natural killer cell activity and neuroimmunological treatment of cancer. Letters to the Editor. Clin Canc Res 10: 8120-8121, 2004

Nylandsted J, Hansen MG, Danielewich A, Fehrenbach N, Hoyer-Hansen M, Lademann U, Multhoff G, Rohde M, Jäättelä M. Hsp70 promotes tumour cell survival by inhibiting lysosomal membrane permeabilization. J Exp Med 200(4): 425-435, 2004

Pfister K, Peleikis A, Fürst A, Multhoff G, Hager T. Adjuvant radiochemotherpay. Does ist use after total mesorectal excision improve the rates of local recurrence and/or the survival rates in patients with rectal carcinoma? Chirurgische Praxis 62(3): 373-382, 2004

Pihusch M, Lohse P, Reitberger J, Hiller E, Andreesen R, Kolb HJ, Holler E, Pihusch R. Impact of thrombophilic gene mutations and graft-versus-host disease on thromboembolic complications after allogeneic hematopoietic stem-cell transplantation. Transplantation. 2004 Sep 27;78(6):911-918.

Pihusch M. Bleeding complications after hematopoietic stem cell transplantation. Semin Hematol. 2004 Jan;41(1 Suppl 1):93-100.

Plentz A, Hahn J, Holler E, Jilg W, Modrow S. Long-term parvovirus B19 viraemia associated with pure red cell aplasia after allogeneic bone marrow transplantation. J Clin Virol. 2004 Sep;31(1):16-9.

Przkora R, Bolder U, Schwarz S, Jauch KW, Spes J, Andreesen R, Mackensen A. Regression of nonresectable inflammatory myofibroblastic tumours after treatment with nonsteroidal anti-inflammatory drugs. Eur J Clin Invest. 2004 Apr;34(4):320-1.

Schmid C, Schleuning M, Aschan J, Ringden O, Hahn J, Holler E, Hegenbart U, Niederwieser D, Dugas M, Ledderose G, Kolb HJ. Low-dose ARAC, donor cells, and GM-CSF for treatment of recurrent acute myeloid leukemia after allogeneic stem cell transplantation. Leukemia. 2004 Aug;18(8):1430-3. No abstract available.

Sostak P, Reich P, Padovan CS, Gerbitz A, Holler E, Straube A. Cerebral Endothelial Expression of Adhesion Molecules in Mice with Chronic Graft-Versus-Host Disease. Stroke. 2004 Apr 8 [Epub ahead of print] [IF 5,3]

Wild PJ, Reichle A, Andreesen R, Rockelein G, Dietmaier W, Ruschoff J, Blaszyk H, Hofstadter F, Hartmann A. Microsatellite instability predicts poor short-term survival in patients with advanced breast cancer after high-dose chemotherapy and autologous stem-cell transplantation.
Clin Cancer Res. 2004 Jan 15;10(2):556-64.

 


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